Homo sapiens Gene: CHST8 | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-42751.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | CHST8 | ||||||||||
Gene Name | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 | ||||||||||
Synonyms | |||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Gene | ENSG00000124302 | ||||||||||
Encoded Proteins |
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 19:33621955-33773509 | ||||||||||
Strand | Forward strand | ||||||||||
Band | q13.11 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | |||||||||||
UniGene | Hs.165724 | ||||||||||
RefSeq | NM_001127895 NM_001127896 NM_022467 | ||||||||||
HUGO | |||||||||||
OMIM | |||||||||||
CCDS | CCDS12433 | ||||||||||
HPRD | 07632 | ||||||||||
IMGT | |||||||||||
EMBL | |||||||||||
GenPept | |||||||||||
RNA Seq Atlas | |||||||||||