InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAMTS9

Summary

InnateDB Gene

IDBG-43120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAMTS9

Gene Name

ADAM metallopeptidase with thrombospondin type 1 motif, 9

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000163638

Encoded Proteins

IDBP-43124

ADAM metallopeptidase with thrombospondin type 1 motif, 9

IDBP-483708

ADAM metallopeptidase with thrombospondin type 1 motif, 9

IDBP-806678

ADAM metallopeptidase with thrombospondin type 1 motif, 9

IDBP-480443

ADAM metallopeptidase with thrombospondin type 1 motif, 9

IDBP-479875

ADAM metallopeptidase with thrombospondin type 1 motif, 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. Members of the ADAMTS family have been implicated in the cleavage of proteoglycans, the control of organ shape during development, and the inhibition of angiogenesis. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:64515654-64688000

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000295903	ENSP00000295903
ENST00000477180
ENST00000498707	ENSP00000418735
ENST00000467257	ENSP00000478086
ENST00000481060	ENSP00000417521
ENST00000482490
ENST00000475557
ENST00000459780	ENSP00000419217
ENST00000467119
ENST00000494004

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0006516	glycoprotein catabolic process
GO:0007275	multicellular organismal development
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0045636	positive regulation of melanocyte differentiation
GO:0048070	regulation of developmental pigmentation

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0031012	extracellular matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030022

View Gene Order

ENSBTAG00000003165

Not yet available

Pathways

NETPATH

REACTOME

REACT_22161

Post-translational protein modification pathway

REACT_118779

Extracellular matrix organization pathway

REACT_118572

Degradation of the extracellular matrix pathway

REACT_200727

O-linked glycosylation pathway

REACT_17015

Metabolism of proteins pathway

REACT_200626

O-glycosylation of TSR domain-containing proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.627120 Hs.656071

RefSeq

NM_182920 XM_005265329

HUGO

OMIM

CCDS

CCDS2903

HPRD

05662

IMGT

EMBL

GenPept

RNA Seq Atlas