Version 5.4
Homo sapiens Gene: MARCH1
Summary
InnateDB Gene IDBG-43339.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH1
Gene Name membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145416
Encoded Proteins
IDBP-43341
membrane-associated ring finger (C3HC4) 1
IDBP-43343
membrane-associated ring finger (C3HC4) 1
IDBP-480197
membrane-associated ring finger (C3HC4) 1
IDBP-482501
membrane-associated ring finger (C3HC4) 1
IDBP-474774
membrane-associated ring finger (C3HC4) 1
IDBP-481649
membrane-associated ring finger (C3HC4) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:163524298-164384050
Strand Reverse strand
Band q32.3
Transcripts
ENST00000274056 ENSP00000274056
ENST00000339875 ENSP00000345676
ENST00000503008 ENSP00000427223
ENST00000514618 ENSP00000421322
ENST00000510786 ENSP00000424089
ENST00000512214
ENST00000505517
ENST00000507270 ENSP00000426731
ENST00000511245
ENST00000510696
ENST00000503104
ENST00000508725
ENST00000505391
ENST00000515471
ENST00000510075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0042287 MHC protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0006955 immune response
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
GO:0031902 late endosome membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036469
View Gene Order
ENSBTAG00000044082
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592804 Hs.595167 Hs.603066 Hs.632596
RefSeq NM_001166373 NM_017923 XM_006714248
HUGO
OMIM
CCDS CCDS3806 CCDS54814
HPRD 07940
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca