InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDK4

Summary

InnateDB Gene

IDBG-43642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDK4

Gene Name

cyclin-dependent kinase 4

Synonyms

CMM3; PSK-J3

Species

Homo sapiens

Ensembl Gene

ENSG00000135446

Encoded Proteins

IDBP-43644

cyclin-dependent kinase 4

IDBP-43646

cyclin-dependent kinase 4

IDBP-596536

cyclin-dependent kinase 4

IDBP-591397

cyclin-dependent kinase 4

IDBP-586118

cyclin-dependent kinase 4

IDBP-604065

cyclin-dependent kinase 4

IDBP-600550

cyclin-dependent kinase 4

IDBP-590909

cyclin-dependent kinase 4

IDBP-596933

cyclin-dependent kinase 4

IDBP-597871

cyclin-dependent kinase 4

IDBP-586990

cyclin-dependent kinase 4

IDBP-590829

cyclin-dependent kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57747727-57756013

Strand

Reverse strand

Band

q14.1

Transcripts

ENST00000257904	ENSP00000257904
ENST00000312990	ENSP00000316889
ENST00000552713
ENST00000549606	ENSP00000447005
ENST00000553237	ENSP00000448885
ENST00000546489	ENSP00000447779
ENST00000551888
ENST00000547281	ENSP00000447274
ENST00000550419	ENSP00000448098
ENST00000551800	ENSP00000449391
ENST00000552254	ENSP00000449179
ENST00000551706
ENST00000552388	ENSP00000448963
ENST00000552862	ENSP00000446763
ENST00000547853	ENSP00000449725

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	163 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030332	cyclin binding
GO:0032403	protein complex binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0002088	lens development in camera-type eye
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007623	circadian rhythm
GO:0008284	positive regulation of cell proliferation
GO:0009636	response to toxic substance
GO:0010033	response to organic substance
GO:0010288	response to lead ion
GO:0010468	regulation of gene expression
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0031100	organ regeneration
GO:0033574	response to testosterone
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0045727	positive regulation of translation
GO:0045793	positive regulation of cell size
GO:0048146	positive regulation of fibroblast proliferation
GO:0051301	cell division
GO:0051726	regulation of cell cycle
GO:0055093	response to hyperoxia
GO:0071157	negative regulation of cell cycle arrest

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005923	tight junction
GO:0031965	nuclear membrane
GO:0048471	perinuclear region of cytoplasm