Version 5.4
Homo sapiens Gene: PLCG2
Summary
InnateDB Gene IDBG-43723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCG2
Gene Name phospholipase C, gamma 2 (phosphatidylinositol-specific)
Synonyms APLAID; FCAS3; PLC-gamma-2; PLC-IV
Species Homo sapiens
Ensembl Gene ENSG00000197943
Encoded Proteins
IDBP-43725
phospholipase C, gamma 2 (phosphatidylinositol-specific)
IDBP-750180
IDBP-751188
IDBP-751035
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22158869
PLCG2, 1,4,5-triphosphate and intracellular calcium are required for the LPS-induced innate immune response pathway, where release of intracellular calcium mediates TLR4 trafficking and subsequent activation of IRF3. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 22158869
[Mus musculus] Plcg2, 1,4,5-triphosphate and intracellular calcium are required for the LPS-induced innate immune response pathway, where release of intracellular calcium mediates Tlr4 trafficking and subsequent activation of Irf3.
Entrez Gene
Summary The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [provided by RefSeq, Sep 2011]
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:81739097-81962693
Strand Forward strand
Band q23.3
Transcripts
ENST00000359376 ENSP00000352336
ENST00000570196
ENST00000565054 ENSP00000455956
ENST00000562605
ENST00000570198
ENST00000565400
ENST00000567980
ENST00000563375 ENSP00000454536
ENST00000567356
ENST00000563193 ENSP00000455533
ENST00000563834
ENST00000563269
ENST00000569523
ENST00000565020
ENST00000567373
ENST00000569929
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0002316 follicular B cell differentiation
GO:0006629 lipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0009395 phospholipid catabolic process
GO:0010468 regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0032237 activation of store-operated calcium channel activity
GO:0032496 response to lipopolysaccharide
GO:0032959 inositol trisphosphate biosynthetic process
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043069 negative regulation of programmed cell death
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034330
View Gene Order
ENSBTAG00000002103
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_16
IL4 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
REACT_163834
FCERI mediated Ca+2 mobilization pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05223
Non-small cell lung cancer pathway
hsa00562
Inositol phosphate metabolism pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa05214
Glioma pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04380
Osteoclast differentiation pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
B cell receptor signaling pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
HGF signaling pathway pathway
INOH website
Inositol phosphate metabolism pathway
PID NCI
epopathway
EPO signaling pathway
bcr_5pathway
BCR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.413111
RefSeq NM_002661
HUGO
OMIM
CCDS CCDS42204
HPRD 02570
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca