Version 5.4
Homo sapiens Gene: MARCH9
Summary
InnateDB Gene IDBG-43731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH9
Gene Name membrane-associated ring finger (C3HC4) 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139266
Encoded Proteins
IDBP-43733
membrane-associated ring finger (C3HC4) 9
IDBP-591929
membrane-associated ring finger (C3HC4) 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57755098-57760407
Strand Forward strand
Band q14.1
Transcripts
ENST00000266643 ENSP00000266643
ENST00000552279
ENST00000548358 ENSP00000446758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005795 Golgi stack
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040502
View Gene Order
ENSBTAG00000016904
Not yet available
Cross-References
SwissProt Q86YJ5
TrEMBL Q8N9T1
UniProt Splice Variant
Entrez Gene 92979
UniGene Hs.609930 Hs.618577 Hs.632709
RefSeq NM_138396
HUGO HGNC:25139
OMIM 613336
CCDS CCDS31847
HPRD 14360
IMGT
EMBL AK093897 AK313925 BC009489 BC036455 BC050397 CH471054
GenPept AAH09489 AAH36455 AAH50397 BAC04247 BAG36646 EAW97065
RNA Seq Atlas 92979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca