Version 5.4
Homo sapiens Gene: SPOCK3
Summary
InnateDB Gene IDBG-43742.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPOCK3
Gene Name sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196104
Encoded Proteins
IDBP-43744
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-43746
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-379536
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-482354
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-474117
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-479052
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-476513
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-481671
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-483941
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-481171
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-482869
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-482144
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-481945
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-483482
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-480532
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-484989
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-481873
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-473879
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-481660
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-475939
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-484344
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-476245
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-475687
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-476485
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-590039
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
IDBP-588760
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:166733384-167234796
Strand Reverse strand
Band q32.3
Transcripts
ENST00000357154 ENSP00000349677
ENST00000357545 ENSP00000350153
ENST00000421836 ENSP00000411344
ENST00000504953 ENSP00000425570
ENST00000506886 ENSP00000420920
ENST00000511531 ENSP00000423421
ENST00000502330 ENSP00000423606
ENST00000510741 ENSP00000426716
ENST00000511905 ENSP00000425712
ENST00000512681 ENSP00000426318
ENST00000511269 ENSP00000425502
ENST00000507370 ENSP00000424677
ENST00000502821 ENSP00000424980
ENST00000505187 ENSP00000422170
ENST00000512648 ENSP00000426177
ENST00000510403 ENSP00000423176
ENST00000515143 ENSP00000425859
ENST00000511226 ENSP00000424674
ENST00000507086 ENSP00000420928
ENST00000502741 ENSP00000422336
ENST00000509854 ENSP00000423367
ENST00000515316 ENSP00000426995
ENST00000506697 ENSP00000424168
ENST00000512042 ENSP00000425407
ENST00000535728 ENSP00000441396
ENST00000541354 ENSP00000444789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008191 metalloendopeptidase inhibitor activity
Biological Process
GO:0007165 signal transduction
GO:0010951 negative regulation of endopeptidase activity
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000054162
View Gene Order
Cross-References
SwissProt Q9BQ16
TrEMBL E7ENM6 Q4W5E2 Q4W5S3
UniProt Splice Variant
Entrez Gene 50859
UniGene Hs.710186
RefSeq NM_001204356 NM_001040159 NM_001204352 NM_001204353 NM_001204354 NM_001204355 NM_001204358 NM_001251967 NM_016950 XM_005263041
HUGO HGNC:13565
OMIM 607989
CCDS CCDS56346 CCDS34095 CCDS54817 CCDS56343 CCDS56344 CCDS56347 CCDS58931 CCDS75207
HPRD 12147
IMGT
EMBL AB056866 AC010103 AC020599 AC023492 AC107210 AJ001454 AK091078 AK294637 AK295015 AK295281 AK295407 AK296291 AK313042 AY358973 BC000460 BC003017 BC013983 CH471056
GenPept AAH00460 AAH03017 AAH13983 AAQ89332 AAY40960 AAY40993 BAB64908 BAG35874 BAG52279 BAG57816 BAG58075 BAG58265 BAG58358 BAG58995 CAA04775 EAX04811
RNA Seq Atlas 50859

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca