Version 5.4
Homo sapiens Gene: SMTN
Summary
InnateDB Gene IDBG-4376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMTN
Gene Name smoothelin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183963
Encoded Proteins
IDBP-4378
smoothelin
IDBP-4380
smoothelin
IDBP-4384
smoothelin
IDBP-294425
smoothelin
IDBP-372441
smoothelin
IDBP-372447
smoothelin
IDBP-372451
smoothelin
IDBP-372452
smoothelin
IDBP-372462
smoothelin
IDBP-372474
smoothelin
IDBP-372480
smoothelin
IDBP-372487
smoothelin
IDBP-812781
smoothelin
IDBP-812804
smoothelin
IDBP-812806
smoothelin
IDBP-812807
smoothelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31064105-31104757
Strand Forward strand
Band q12.2
Transcripts
ENST00000333137 ENSP00000329532
ENST00000358743 ENSP00000351593
ENST00000347557 ENSP00000328635
ENST00000404574 ENSP00000383919
ENST00000432777 ENSP00000398663
ENST00000422839 ENSP00000390453
ENST00000440425 ENSP00000401341
ENST00000426927 ENSP00000399432
ENST00000438223 ENSP00000409925
ENST00000416786 ENSP00000409990
ENST00000431481 ENSP00000394637
ENST00000455608 ENSP00000392329
ENST00000482444 ENSP00000485277
ENST00000475548
ENST00000497697
ENST00000489337
ENST00000460658
ENST00000466272
ENST00000493335
ENST00000472911
ENST00000624247 ENSP00000485089
ENST00000612341 ENSP00000479578
ENST00000619644 ENSP00000484398
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006939 smooth muscle contraction
GO:0007517 muscle organ development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020439
View Gene Order
ENSBTAG00000003100
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.738578
RefSeq NM_001207017 NM_001207018 NM_006932 NM_134269 NM_134270 XM_006724298 XM_006724303 XM_006724306
HUGO
OMIM
CCDS CCDS13886 CCDS13887 CCDS13888 CCDS74845 CCDS74846
HPRD 03675
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca