Version 5.4
Homo sapiens Gene: PTPRJ
Summary
InnateDB Gene IDBG-44058.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRJ
Gene Name protein tyrosine phosphatase, receptor type, J
Synonyms CD148; DEP1; HPTPeta; R-PTP-ETA; SCC1
Species Homo sapiens
Ensembl Gene ENSG00000149177
Encoded Proteins
IDBP-373871
protein tyrosine phosphatase, receptor type, J
IDBP-373872
protein tyrosine phosphatase, receptor type, J
IDBP-597191
protein tyrosine phosphatase, receptor type, J
IDBP-586360
protein tyrosine phosphatase, receptor type, J
IDBP-813296
protein tyrosine phosphatase, receptor type, J
IDBP-813297
protein tyrosine phosphatase, receptor type, J
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47980558-48170841
Strand Forward strand
Band p11.2
Transcripts
ENST00000418331 ENSP00000400010
ENST00000440289 ENSP00000409733
ENST00000534219 ENSP00000432686
ENST00000527952 ENSP00000435618
ENST00000526550
ENST00000527026
ENST00000613246 ENSP00000477933
ENST00000615445 ENSP00000479342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0045295 gamma-catenin binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070097 delta-catenin binding
Biological Process
GO:0001570 vasculogenesis
GO:0006470 protein dephosphorylation
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016311 dephosphorylation
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043116 negative regulation of vascular permeability
GO:0043407 negative regulation of MAP kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048709 oligodendrocyte differentiation
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050918 positive chemotaxis
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0060242 contact inhibition
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0009986 cell surface
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025314
View Gene Order
ENSBTAG00000024715
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.318547
RefSeq NM_001098503 NM_002843 XM_006718269
HUGO
OMIM
CCDS CCDS44596 CCDS7945
HPRD 02955
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca