Version 5.4
Homo sapiens Gene: USP15
Summary
InnateDB Gene IDBG-44309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP15
Gene Name ubiquitin specific peptidase 15
Synonyms UNPH-2; UNPH4
Species Homo sapiens
Ensembl Gene ENSG00000135655
Encoded Proteins
IDBP-44311
ubiquitin specific peptidase 15
IDBP-44313
ubiquitin specific peptidase 15
IDBP-44315
ubiquitin specific peptidase 15
IDBP-593590
ubiquitin specific peptidase 15
IDBP-590768
ubiquitin specific peptidase 15
IDBP-596733
ubiquitin specific peptidase 15
IDBP-593605
ubiquitin specific peptidase 15
IDBP-586210
ubiquitin specific peptidase 15
IDBP-588665
ubiquitin specific peptidase 15
IDBP-588476
ubiquitin specific peptidase 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:62260338-62417431
Strand Forward strand
Band q14.1
Transcripts
ENST00000280377 ENSP00000280377
ENST00000312635 ENSP00000309240
ENST00000353364 ENSP00000258123
ENST00000549523 ENSP00000447603
ENST00000550632
ENST00000548524
ENST00000546718
ENST00000551206
ENST00000537297
ENST00000549237 ENSP00000448393
ENST00000548836 ENSP00000446843
ENST00000546694 ENSP00000449563
ENST00000552997 ENSP00000447367
ENST00000547317
ENST00000549268
ENST00000549415 ENSP00000448372
ENST00000548620 ENSP00000446559
ENST00000552346
ENST00000549101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
Experimentally validated
Total 137 [view]
Protein-Protein 136 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005160 transforming growth factor beta receptor binding
GO:0036459 ubiquitinyl hydrolase activity
GO:0042802 identical protein binding
GO:0046332 SMAD binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008152 metabolic process
GO:0016579 protein deubiquitination
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0035520 monoubiquitinated protein deubiquitination
GO:0060389 pathway-restricted SMAD protein phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020124
View Gene Order
ENSBTAG00000010428
Not yet available
Pathways
NETPATH
REACTOME
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VVY7
UniProt Splice Variant
Entrez Gene 9958
UniGene Hs.434951
RefSeq NM_001252078 NM_001252079 NM_006313 XM_005269259 XM_005269261 XM_006719718
HUGO HGNC:12613
OMIM 604731
CCDS CCDS58250 CCDS58251 CCDS8963
HPRD 05293
IMGT
EMBL AC048342 AC079035 AC117370
GenPept
RNA Seq Atlas 9958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca