InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FOLH1

Summary

InnateDB Gene

IDBG-44485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOLH1

Gene Name

folate hydrolase (prostate-specific membrane antigen) 1

Synonyms

FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA

Species

Homo sapiens

Ensembl Gene

ENSG00000086205

Encoded Proteins

IDBP-44487

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-44489

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-44491

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-44495

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-596150

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-583835

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-601487

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-603787

folate hydrolase (prostate-specific membrane antigen) 1

IDBP-596063

folate hydrolase (prostate-specific membrane antigen) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:49146635-49208670

Strand

Reverse strand

Band

p11.12

Transcripts

ENST00000256999	ENSP00000256999
ENST00000356696	ENSP00000349129
ENST00000343844	ENSP00000344086
ENST00000340334	ENSP00000344131
ENST00000458311
ENST00000525826	ENSP00000434928
ENST00000533034	ENSP00000431463
ENST00000532018
ENST00000525629
ENST00000526226
ENST00000529646
ENST00000533510	ENSP00000436569
ENST00000529117	ENSP00000431577
ENST00000529648	ENSP00000431263

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016805	dipeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0006760	folic acid-containing compound metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001773

View Gene Order

ENSBTAG00000007397

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00250

Alanine, aspartate and glutamate metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PKM3

UniProt Splice Variant

Entrez Gene

2346

UniGene

Hs.654487

RefSeq

NM_001014986 NM_001193471 NM_001193472 NM_001193473 NM_004476 XM_006718776

HUGO

HGNC:3788

OMIM

600934 609020

CCDS

CCDS31493 CCDS53626 CCDS53627 CCDS53628 CCDS7946

HPRD

02961

IMGT

EMBL

AC110742 AC118273

GenPept

RNA Seq Atlas

219595 2346