InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP4A

Summary

InnateDB Gene

IDBG-44541.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP4A

Gene Name

ATPase, H+/K+ exchanging, alpha polypeptide

Synonyms

ATP6A

Species

Homo sapiens

Ensembl Gene

ENSG00000105675

Encoded Proteins

IDBP-44543

ATPase, H+/K+ exchanging, alpha polypeptide

IDBP-760061

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:35550043-35563658

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000262623	ENSP00000262623
ENST00000592131
ENST00000592767	ENSP00000472323
ENST00000590916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.

Experimentally validated
Total	76 [view]
Protein-Protein	76 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0008900	hydrogen:potassium-exchanging ATPase activity
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0010155	regulation of proton transport
GO:0015672	monovalent inorganic cation transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0034220	ion transmembrane transport
GO:0042493	response to drug
GO:0045851	pH reduction
GO:0055085	transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005553

View Gene Order

ENSBTAG00000008777

Not yet available

Pathways

NETPATH

REACTOME

REACT_25149

Ion transport by P-type ATPases pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

hsa04971

Gastric acid secretion pathway

hsa04966

Collecting duct acid secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

495

UniGene

Hs.36992

RefSeq

NM_000704

HUGO

HGNC:819

OMIM

137216

CCDS

CCDS12467

HPRD

00668

IMGT

EMBL

GenPept

RNA Seq Atlas

495