Version 5.4
Homo sapiens Gene: AVPR1A
Summary
InnateDB Gene IDBG-44561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AVPR1A
Gene Name arginine vasopressin receptor 1A
Synonyms AVPR V1a; AVPR1; V1aR
Species Homo sapiens
Ensembl Gene ENSG00000166148
Encoded Proteins
IDBP-44563
arginine vasopressin receptor 1A
IDBP-600001
arginine vasopressin receptor 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:63142759-63150942
Strand Reverse strand
Band q14.2
Transcripts
ENST00000299178 ENSP00000299178
ENST00000550940 ENSP00000449822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005000 vasopressin receptor activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0031894 V1A vasopressin receptor binding
Biological Process
GO:0001992 regulation of systemic arterial blood pressure by vasopressin
GO:0002125 maternal aggressive behavior
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006091 generation of precursor metabolites and energy
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007621 negative regulation of female receptivity
GO:0007625 grooming behavior
GO:0008015 blood circulation
GO:0008284 positive regulation of cell proliferation
GO:0010033 response to organic substance
GO:0010035 response to inorganic substance
GO:0010460 positive regulation of heart rate
GO:0014049 positive regulation of glutamate secretion
GO:0014902 myotube differentiation
GO:0019722 calcium-mediated signaling
GO:0021537 telencephalon development
GO:0030307 positive regulation of cell growth
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0032849 positive regulation of cellular pH reduction
GO:0035176 social behavior
GO:0035815 positive regulation of renal sodium excretion
GO:0042631 cellular response to water deprivation
GO:0042711 maternal behavior
GO:0042713 sperm ejaculation
GO:0043084 penile erection
GO:0045777 positive regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0051412 response to corticosterone
GO:0051970 negative regulation of transmission of nerve impulse
Cellular Component
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020123
View Gene Order
ENSBTAG00000007175
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_17041
Vasopressin-like receptors pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt P37288
TrEMBL F8VW98 X5D2B0
UniProt Splice Variant
Entrez Gene 552
UniGene Hs.2131
RefSeq NM_000706 XM_005269002
HUGO HGNC:895
OMIM 600821
CCDS CCDS8965
HPRD
IMGT
EMBL AC135584 AF030625 AF101725 AY322550 BC074803 BC074804 KJ534779 L25615 S73899 U19906
GenPept AAA62271 AAB19232 AAC51861 AAC60638 AAD17891 AAH74803 AAH74804 AAP84363 AHW56419
RNA Seq Atlas 552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca