Version 5.4
Homo sapiens Gene: VLDLR
Summary
InnateDB Gene IDBG-44752.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VLDLR
Gene Name very low density lipoprotein receptor
Synonyms CARMQ1; CHRMQ1; VLDLRCH
Species Homo sapiens
Ensembl Gene ENSG00000147852
Encoded Proteins
IDBP-44756
very low density lipoprotein receptor
IDBP-44758
very low density lipoprotein receptor
IDBP-44760
very low density lipoprotein receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21642441
VLDLR is exploited by rhinovirus for viral entry. VLDLR protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B.
InnateDB Annotation from Orthologs
Summary
PMID 21642441
[Mus musculus] Vldlr is exploited by rhinovirus for viral entry. Vldlr protein levels are negatively regulated by IFN/RIG-I signalling via MIR23B. (Demonstrated in human)
Entrez Gene
Summary The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:2621834-2660053
Strand Forward strand
Band p24.2
Transcripts
ENST00000382100 ENSP00000371532
ENST00000382099 ENSP00000371531
ENST00000382096 ENSP00000371528
ENST00000478776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005041 low-density lipoprotein receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030229 very-low-density lipoprotein particle receptor activity
GO:0034185 apolipoprotein binding
GO:0034189 very-low-density lipoprotein particle binding
GO:0034437 glycoprotein transporter activity
GO:0038025 reelin receptor activity
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006869 lipid transport
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007613 memory
GO:0008203 cholesterol metabolic process
GO:0021517 ventral spinal cord development
GO:0034436 glycoprotein transport
GO:0034447 very-low-density lipoprotein particle clearance
GO:0038026 reelin-mediated signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045860 positive regulation of protein kinase activity
GO:1900006 positive regulation of dendrite development
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034361 very-low-density lipoprotein particle
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024924
View Gene Order
ENSBTAG00000018517
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
reelinpathway
Reelin signaling pathway
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt P98155
TrEMBL A8K0G2 Q5VVF5 Q5VVF8
UniProt Splice Variant
Entrez Gene 7436
UniGene Hs.370422
RefSeq NM_001018056 NM_003383 XM_006716864 XM_006716865
HUGO HGNC:12698
OMIM 192977
CCDS CCDS34979 CCDS6446
HPRD
IMGT
EMBL AK289527 AL450467 BC136562 BC142653 BC144245 CH471071 D16493 D16494 D16532 DQ067198 L20470 L22431 S73849
GenPept AAA53684 AAA61344 AAB31735 AAI36563 AAI42654 AAI44246 AAY46157 BAA03945 BAA03946 BAA03969 BAF82216 CAH72454 EAW58804 EAW58805 EAW58806 EAW58807
RNA Seq Atlas 7436

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca