Version 5.4
Homo sapiens Gene: UBE2B
Summary
InnateDB Gene IDBG-44827.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2B
Gene Name ubiquitin-conjugating enzyme E2B
Synonyms E2-17kDa; HHR6B; HR6B; RAD6B; UBC2
Species Homo sapiens
Ensembl Gene ENSG00000119048
Encoded Proteins
IDBP-44829
ubiquitin-conjugating enzyme E2B
IDBP-477965
ubiquitin-conjugating enzyme E2B
IDBP-481242
ubiquitin-conjugating enzyme E2B
IDBP-484174
ubiquitin-conjugating enzyme E2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100%% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134371179-134391992
Strand Forward strand
Band q31.1
Transcripts
ENST00000265339 ENSP00000265339
ENST00000510021 ENSP00000425237
ENST00000511807
ENST00000506787 ENSP00000426364
ENST00000507277 ENSP00000425137
ENST00000504431
ENST00000499038
ENST00000503080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 71 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0006281 DNA repair
GO:0006301 postreplication repair
GO:0006344 maintenance of chromatin silencing
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0007283 spermatogenesis
GO:0007288 sperm axoneme assembly
GO:0008152 metabolic process
GO:0009411 response to UV
GO:0010845 positive regulation of reciprocal meiotic recombination
GO:0016567 protein ubiquitination
GO:0031056 regulation of histone modification
GO:0032869 cellular response to insulin stimulus
GO:0033128 negative regulation of histone phosphorylation
GO:0033522 histone H2A ubiquitination
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0050821 protein stabilization
GO:0051026 chiasma assembly
GO:0051865 protein autoubiquitination
GO:0060070 canonical Wnt signaling pathway
GO:0070076 histone lysine demethylation
GO:0070193 synaptonemal complex organization
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0001741 XY body
GO:0005634 nucleus
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0033503 HULC complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020390
View Gene Order
ENSBTAG00000010982
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.612096 Hs.714626
RefSeq NM_003337
HUGO
OMIM
CCDS CCDS4174
HPRD 01533
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca