InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OXT

Summary

InnateDB Gene

IDBG-45397.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXT

Gene Name

oxytocin/neurophysin I prepropeptide

Synonyms

OT; OT-NPI; OXT-NPI

Species

Homo sapiens

Ensembl Gene

ENSG00000101405

Encoded Proteins

IDBP-45399

oxytocin, prepropeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Jul 2008]
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:3071620-3072517

Strand

Forward strand

Band

p13

Transcripts

ENST00000217386

ENSP00000217386

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005185	neurohypophyseal hormone activity
GO:0005515	protein binding
GO:0031855	oxytocin receptor binding

Biological Process

GO:0001975	response to amphetamine
GO:0002027	regulation of heart rate
GO:0002125	maternal aggressive behavior
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007507	heart development
GO:0007565	female pregnancy
GO:0007613	memory
GO:0007625	grooming behavior
GO:0009744	response to sucrose stimulus
GO:0010701	positive regulation of norepinephrine secretion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0030431	sleep
GO:0032094	response to food
GO:0032308	positive regulation of prostaglandin secretion
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0034695	response to prostaglandin E
GO:0035176	social behavior
GO:0035811	negative regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042220	response to cocaine
GO:0042538	hyperosmotic salinity response
GO:0042711	maternal behavior
GO:0042713	sperm ejaculation
GO:0042755	eating behavior
GO:0042756	drinking behavior
GO:0043434	response to peptide hormone
GO:0044058	regulation of digestive system process
GO:0045472	response to ether
GO:0045776	negative regulation of blood pressure
GO:0045777	positive regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045925	positive regulation of female receptivity
GO:0048545	response to steroid hormone
GO:0050806	positive regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0051602	response to electrical stimulus
GO:0051930	regulation of sensory perception of pain
GO:0051965	positive regulation of synapse assembly
GO:0060179	male mating behavior
GO:0060406	positive regulation of penile erection
GO:0060450	positive regulation of hindgut contraction
GO:0060455	negative regulation of gastric acid secretion
GO:0070474	positive regulation of uterine smooth muscle contraction