Version 5.4
Homo sapiens Gene: KEL
Summary
InnateDB Gene IDBG-45408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KEL
Gene Name Kell blood group, metallo-endopeptidase
Synonyms CD238; ECE3
Species Homo sapiens
Ensembl Gene ENSG00000197993
Encoded Proteins
IDBP-45410
Kell blood group, metallo-endopeptidase
IDBP-485019
Kell blood group, metallo-endopeptidase
IDBP-477379
Kell blood group, metallo-endopeptidase
IDBP-480498
Kell blood group, metallo-endopeptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:142941114-142962681
Strand Reverse strand
Band q34
Transcripts
ENST00000355265 ENSP00000347409
ENST00000470850
ENST00000478969
ENST00000465697
ENST00000479768
ENST00000494148
ENST00000476829 ENSP00000419889
ENST00000467543 ENSP00000420011
ENST00000460479 ENSP00000418886
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0042310 vasoconstriction
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029866
View Gene Order
ENSBTAG00000014533
Not yet available
Cross-References
SwissProt P23276
TrEMBL A3F6J8 A8YPS5 E7ETW3 E9PHG0 Q06AK5 Q09GN6 Q0KH83 Q0KH84 Q0KH85 Q0KH86 Q0KH87 Q0KH89 Q0KH93 Q0KH97 W5XPJ0
UniProt Splice Variant
Entrez Gene 3792
UniGene Hs.368588
RefSeq NM_000420 XM_005249993 XM_005249994 XM_005276988 XM_005276989
HUGO HGNC:6308
OMIM 613883
CCDS CCDS34766
HPRD
IMGT
EMBL AC099652 AF172609 AF172610 AF172611 AF172612 AF172613 AF172614 AF172615 AF172616 AF172617 AF172618 AF172619 AF172620 AF172621 AF172622 AF172623 AF172624 AF172625 AF172626 AF172627 AF279657 AK314831 AM085113 AM085114 AM085115 AM085117 AM085118 AM085122 AM085124 AM085125 AM085126 AM085127 AM085128 AM902715 AY228336 BC003135 BC050639 CH471198 DQ905957 DQ923321 EF208899 KF993655 M64934 S80081
GenPept AAA03192 AAB33459 AAB47018 AAH03135 AAH50639 AAK69488 AAO38053 ABI75043 ABI96895 ABN11470 AHI18583 BAG37351 CAJ30267 CAJ30268 CAJ30269 CAJ30271 CAJ30272 CAJ30276 CAJ30278 CAJ30279 CAJ30280 CAJ30281 CAJ30282 CAP18775 EAW51891
RNA Seq Atlas 3792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca