Homo sapiens Gene: RFX3 | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-45438.6 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | RFX3 | ||||||||||||||||||||||||||||||
Gene Name | regulatory factor X, 3 (influences HLA class II expression) | ||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000080298 | ||||||||||||||||||||||||||||||
Encoded Proteins |
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
regulatory factor X, 3 (influences HLA class II expression)
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals. [provided by RefSeq, Jul 2008] This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 9:3218297-3526004 | ||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||
Band | p24.2 | ||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||||||||||
SwissProt | P48380 | ||||||||||||||||||||||||||||||
TrEMBL | F6USP3 F6XM74 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 5991 | ||||||||||||||||||||||||||||||
UniGene | Hs.136829 Hs.438858 Hs.596860 Hs.625122 Hs.631051 Hs.696660 Hs.713388 Hs.734648 | ||||||||||||||||||||||||||||||
RefSeq | NM_134428 XM_005251534 NM_001282116 NM_001282117 NM_002919 | ||||||||||||||||||||||||||||||
HUGO | HGNC:9984 | ||||||||||||||||||||||||||||||
OMIM | 601337 | ||||||||||||||||||||||||||||||
CCDS | CCDS6449 CCDS6450 CCDS75809 | ||||||||||||||||||||||||||||||
HPRD | 03215 | ||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | AK289540 AL133549 AL354941 AL365202 AL603631 BC022191 BC067778 CH471071 X76092 | ||||||||||||||||||||||||||||||
GenPept | AAH22191 AAH67778 BAF82229 CAA53706 CAI13403 CAI13404 CAI40199 CAI40200 CAI41215 CAI41216 EAW58795 EAW58796 EAW58798 EAW58799 | ||||||||||||||||||||||||||||||
RNA Seq Atlas | 5991 | ||||||||||||||||||||||||||||||