Version 5.4
Homo sapiens Gene: RFX3
Summary
InnateDB Gene IDBG-45438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFX3
Gene Name regulatory factor X, 3 (influences HLA class II expression)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000080298
Encoded Proteins
IDBP-45440
regulatory factor X, 3 (influences HLA class II expression)
IDBP-45444
regulatory factor X, 3 (influences HLA class II expression)
IDBP-45446
regulatory factor X, 3 (influences HLA class II expression)
IDBP-45452
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361784
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361797
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361799
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361801
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361805
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361809
regulatory factor X, 3 (influences HLA class II expression)
IDBP-361813
regulatory factor X, 3 (influences HLA class II expression)
IDBP-807427
regulatory factor X, 3 (influences HLA class II expression)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:3218297-3526004
Strand Reverse strand
Band p24.2
Transcripts
ENST00000382004 ENSP00000371434
ENST00000302303 ENSP00000303847
ENST00000358730 ENSP00000351574
ENST00000381984 ENSP00000371414
ENST00000449234 ENSP00000415594
ENST00000458034 ENSP00000400026
ENST00000457373 ENSP00000405664
ENST00000451859 ENSP00000411756
ENST00000442560 ENSP00000410988
ENST00000420720 ENSP00000416189
ENST00000449190 ENSP00000399352
ENST00000617270 ENSP00000482598
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007368 determination of left/right symmetry
GO:0031018 endocrine pancreas development
GO:0042384 cilium assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0050796 regulation of insulin secretion
GO:0060285 cilium-dependent cell motility
GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry
GO:0072560 type B pancreatic cell maturation
GO:2000078 positive regulation of type B pancreatic cell development
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040929
View Gene Order
ENSBTAG00000000819
Not yet available
Cross-References
SwissProt P48380
TrEMBL F6USP3 F6XM74
UniProt Splice Variant
Entrez Gene 5991
UniGene Hs.136829 Hs.438858 Hs.596860 Hs.625122 Hs.631051 Hs.696660 Hs.713388 Hs.734648
RefSeq NM_134428 XM_005251534 NM_001282116 NM_001282117 NM_002919
HUGO HGNC:9984
OMIM 601337
CCDS CCDS6449 CCDS6450 CCDS75809
HPRD 03215
IMGT
EMBL AK289540 AL133549 AL354941 AL365202 AL603631 BC022191 BC067778 CH471071 X76092
GenPept AAH22191 AAH67778 BAF82229 CAA53706 CAI13403 CAI13404 CAI40199 CAI40200 CAI41215 CAI41216 EAW58795 EAW58796 EAW58798 EAW58799
RNA Seq Atlas 5991

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca