Version 5.4
Homo sapiens Gene: PRKD3
Summary
InnateDB Gene IDBG-45514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKD3
Gene Name protein kinase D3
Synonyms EPK2; nPKC-NU; PKC-NU; PKD3; PRKCN
Species Homo sapiens
Ensembl Gene ENSG00000115825
Encoded Proteins
IDBP-45516
protein kinase D3
IDBP-45518
protein kinase D3
IDBP-372702
protein kinase D3
IDBP-372707
protein kinase D3
IDBP-372711
protein kinase D3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:37250502-37324808
Strand Reverse strand
Band p22.2
Transcripts
ENST00000379066 ENSP00000368356
ENST00000234179 ENSP00000234179
ENST00000452104 ENSP00000399540
ENST00000443977 ENSP00000398743
ENST00000443187 ENSP00000401839
ENST00000469275
ENST00000494667
ENST00000475912
ENST00000464552
ENST00000477132
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009103 lipopolysaccharide biosynthetic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024070
View Gene Order
ENSBTAG00000001114
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.660757
RefSeq NM_005813 XM_005264237 XM_005264238 XM_006711978 XM_006711979 XM_006711980
HUGO
OMIM
CCDS CCDS1789
HPRD 06151
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca