Version 5.4
Homo sapiens Gene: GLRA2
Summary
InnateDB Gene IDBG-45609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRA2
Gene Name glycine receptor, alpha 2
Synonyms GLR
Species Homo sapiens
Ensembl Gene ENSG00000101958
Encoded Proteins
IDBP-45611
glycine receptor, alpha 2
IDBP-45613
glycine receptor, alpha 2
IDBP-362359
glycine receptor, alpha 2
IDBP-362360
glycine receptor, alpha 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:14529298-14731812
Strand Forward strand
Band p22.2
Transcripts
ENST00000218075 ENSP00000218075
ENST00000355020 ENSP00000347123
ENST00000443437 ENSP00000387756
ENST00000415367 ENSP00000391606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005230 extracellular ligand-gated ion channel activity
GO:0016594 glycine binding
GO:0016934 extracellular-glycine-gated chloride channel activity
GO:0022824 transmitter-gated ion channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007218 neuropeptide signaling pathway
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018589
View Gene Order
ENSBTAG00000017209
Not yet available
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt P23416
TrEMBL
UniProt Splice Variant
Entrez Gene 2742
UniGene Hs.2700 Hs.641859
RefSeq NM_001171942 NM_001118885 NM_001118886 NM_002063
HUGO HGNC:4327
OMIM 305990
CCDS CCDS55371 CCDS14160 CCDS48085
HPRD 02379
IMGT
EMBL AC003658 AC003683 AF053487 AF053488 AF053489 AF053490 AF053491 AF053492 AF053493 AF053494 AF053495 AK289561 AK297304 AK312591 AY437083 AY437084 BC032864 CH471074 CR450343 U77724 U77725 U77726 U77727 U77728 U77729 U77730 U77731 X52008
GenPept AAB38272 AAB38273 AAC35290 AAH32864 AAR87842 AAR87843 BAF82250 BAG35485 BAH12541 CAA36257 CAG29339 EAW98859 EAW98860
RNA Seq Atlas 2742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca