InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED1

Summary

InnateDB Gene

IDBG-45623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED1

Gene Name

mediator complex subunit 1

Synonyms

CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2

Species

Homo sapiens

Ensembl Gene

ENSG00000125686

Encoded Proteins

IDBP-45625

mediator complex subunit 1

IDBP-241890

mediator complex subunit 1

IDBP-762756

IDBP-758950

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:39404285-39451286

Strand

Reverse strand

Band

q12

Transcripts

ENST00000300651	ENSP00000300651
ENST00000394287	ENSP00000377828
ENST00000577831	ENSP00000463307
ENST00000581334	ENSP00000462441
ENST00000584308

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	159 [view]
Protein-DNA	9 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047	core promoter binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0031490	chromatin DNA binding
GO:0032403	protein complex binding
GO:0035257	nuclear hormone receptor binding
GO:0036033	mediator complex binding
GO:0042809	vitamin D receptor binding
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0050693	LBD domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0002088	lens development in camera-type eye
GO:0002154	thyroid hormone mediated signaling pathway
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003406	retinal pigment epithelium development
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006590	thyroid hormone generation
GO:0006702	androgen biosynthetic process
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007507	heart development
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0010628	positive regulation of gene expression
GO:0010839	negative regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030224	monocyte differentiation
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0031100	organ regeneration
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033598	mammary gland epithelial cell proliferation
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0035050	embryonic heart tube development
GO:0035116	embryonic hindlimb morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035855	megakaryocyte development
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045444	fat cell differentiation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048821	erythrocyte development
GO:0048822	enucleate erythrocyte development
GO:0051726	regulation of cell cycle
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744	mammary gland branching involved in thelarche
GO:0060745	mammary gland branching involved in pregnancy
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318	positive regulation of G0 to G1 transition
GO:0070371	ERK1 and ERK2 cascade
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071383	cellular response to steroid hormone stimulus
GO:0097067	cellular response to thyroid hormone stimulus
GO:2000273	positive regulation of receptor activity
GO:2000347	positive regulation of hepatocyte proliferation
GO:2001141	regulation of RNA biosynthetic process