Version 5.4
Homo sapiens Gene: HELB
Summary
InnateDB Gene IDBG-45661.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HELB
Gene Name helicase (DNA) B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127311
Encoded Proteins
IDBP-45663
helicase (DNA) B
IDBP-379561
helicase (DNA) B
IDBP-602201
helicase (DNA) B
IDBP-590146
helicase (DNA) B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:66302545-66347645
Strand Forward strand
Band q14.3
Transcripts
ENST00000247815 ENSP00000247815
ENST00000440906 ENSP00000396955
ENST00000542394 ENSP00000439617
ENST00000545134 ENSP00000443287
ENST00000545455
ENST00000536862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004003 ATP-dependent DNA helicase activity
GO:0005524 ATP binding
GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006269 DNA replication, synthesis of RNA primer
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0005658 alpha DNA polymerase:primase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020228
View Gene Order
ENSBTAG00000020806
Not yet available
Cross-References
SwissProt
TrEMBL F5H1I4
UniProt Splice Variant
Entrez Gene 92797
UniGene Hs.505941
RefSeq NM_033647 XM_005269234
HUGO HGNC:17196
OMIM 614539
CCDS CCDS8976
HPRD 09979
IMGT
EMBL AC078889
GenPept
RNA Seq Atlas 92797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca