Homo sapiens Gene: CHMP2B
Summary
InnateDB Gene IDBG-45704.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol CHMP2B
Gene Name charged multivesicular body protein 2B
Synonyms ALS17; CHMP2.5; DMT1; VPS2-2; VPS2B;
Species Homo sapiens
Ensembl Gene ENSG00000083937
Encoded Proteins
charged multivesicular body protein 2B
charged multivesicular body protein 2B
charged multivesicular body protein 2B
Protein Structure
Entrez Gene
Summary This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:87276421-87304698
Strand Forward strand
Band p11.2
Transcripts
ENST00000263780 ENSP00000263780
ENST00000471660 ENSP00000419998
ENST00000494980 ENSP00000418920
ENST00000472024
ENST00000466696
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0019904 protein domain specific binding
Biological Process
GO:0008219 cell death
GO:0015031 protein transport
GO:0016044 cellular membrane organization
GO:0016197 endosomal transport
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0031902 late endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UQN3
TrEMBL B2RE76 B4DJG8 C9J0A7
UniProt Splice Variant
Entrez Gene 25978
UniGene Hs.476930
RefSeq NM_014043
HUGO 24537
OMIM 609512
CCDS CCDS2918
HPRD 13174
IMGT
EMBL AC123511 AC130885 AF151842 AK002165 AK002180 AK222654 AK296072 AK316585 AL080122 BC001553 CH471110 CR533456
GenPept AAD34079 AAH01553 BAD96374 BAG38173 BAG51022 BAG51025 BAG58830 CAB45721 CAG38487 EAW68868
ImmGen CHMP2B (murine)
RNA Seq Atlas 25978