InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POU1F1

Summary

InnateDB Gene

IDBG-45748.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POU1F1

Gene Name

POU class 1 homeobox 1

Synonyms

CPHD1; GHF-1; Pit-1; PIT1; POU1F1a

Species

Homo sapiens

Ensembl Gene

ENSG00000064835

Encoded Proteins

IDBP-45750

POU class 1 homeobox 1

IDBP-45752

POU class 1 homeobox 1

IDBP-595482

POU class 1 homeobox 1

IDBP-599165

POU class 1 homeobox 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:87259404-87276587

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000344265	ENSP00000342931
ENST00000350375	ENSP00000263781
ENST00000561167	ENSP00000454072
ENST00000560656	ENSP00000452610

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008340	determination of adult lifespan
GO:0021983	pituitary gland development
GO:0021984	adenohypophysis development
GO:0030183	B cell differentiation
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0040018	positive regulation of multicellular organism growth
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051169	nuclear transport
GO:0060126	somatotropin secreting cell differentiation
GO:0060133	somatotropin secreting cell development

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000004842

View Gene Order

ENSBTAG00000009128

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

reg_gr_pathway

Glucocorticoid receptor regulatory network

Cross-References

SwissProt

TrEMBL

H0YNM5

UniProt Splice Variant

Entrez Gene

5449

UniGene

Hs.591654 Hs.89394

RefSeq

NM_000306 NM_001122757

HUGO

HGNC:9210

OMIM

173110

CCDS

CCDS2919 CCDS46873

HPRD

01409

IMGT

EMBL

AC130885

GenPept

RNA Seq Atlas

5449