Version 5.4
Homo sapiens Gene: CDC42EP3
Summary
InnateDB Gene IDBG-45802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP3
Gene Name CDC42 effector protein (Rho GTPase binding) 3
Synonyms BORG2; CEP3; UB1
Species Homo sapiens
Ensembl Gene ENSG00000163171
Encoded Proteins
IDBP-45804
CDC42 effector protein (Rho GTPase binding) 3
IDBP-372733
CDC42 effector protein (Rho GTPase binding) 3
IDBP-372735
CDC42 effector protein (Rho GTPase binding) 3
IDBP-372736
CDC42 effector protein (Rho GTPase binding) 3
IDBP-812146
CDC42 effector protein (Rho GTPase binding) 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:37641882-37738468
Strand Reverse strand
Band p22.2
Transcripts
ENST00000295324 ENSP00000295324
ENST00000457889 ENSP00000403298
ENST00000453555 ENSP00000398062
ENST00000422687 ENSP00000409147
ENST00000494083
ENST00000611976 ENSP00000480549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005519 cytoskeletal regulatory protein binding
Biological Process
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
Cellular Component
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036533
View Gene Order
ENSBTAG00000023736
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369574 Hs.636182 Hs.689535 Hs.743363
RefSeq NM_001270436 NM_001270437 NM_001270438 NM_006449
HUGO
OMIM
CCDS CCDS1791
HPRD 09364
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca