Homo sapiens Gene: DYRK2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-45841.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | DYRK2 | ||||||||||||||||||||||
Gene Name | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000127334 | ||||||||||||||||||||||
Encoded Proteins |
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008] DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5\' terminal insert. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:67648338-67665406 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q15 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
p53 pathway
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Cross-References | |||||||||||||||||||||||
SwissProt | Q92630 | ||||||||||||||||||||||
TrEMBL | F5GXG1 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 8445 | ||||||||||||||||||||||
UniGene | Hs.173135 Hs.606656 Hs.618871 Hs.732280 Hs.733040 | ||||||||||||||||||||||
RefSeq | NM_003583 NM_006482 | ||||||||||||||||||||||
HUGO | HGNC:3093 | ||||||||||||||||||||||
OMIM | 603496 | ||||||||||||||||||||||
CCDS | CCDS8979 CCDS8978 | ||||||||||||||||||||||
HPRD | 04606 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC078777 AK313937 BC005809 BC006375 CH471054 Y09216 Y13493 | ||||||||||||||||||||||
GenPept | AAH05809 AAH06375 BAG36656 CAA70418 CAA73885 EAW97176 | ||||||||||||||||||||||
RNA Seq Atlas | 8445 | ||||||||||||||||||||||