InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC1A1

Summary

InnateDB Gene

IDBG-45967.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC1A1

Gene Name

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Synonyms

DCBXA; EAAC1; EAAT3; SCZD18

Species

Homo sapiens

Ensembl Gene

ENSG00000106688

Encoded Proteins

IDBP-45969

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

IDBP-361927

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:4490444-4587469

Strand

Forward strand

Band

p24.2

Transcripts

ENST00000262352	ENSP00000262352
ENST00000422398	ENSP00000414620
ENST00000490167

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005313	L-glutamate transmembrane transporter activity
GO:0005515	protein binding
GO:0015501	glutamate:sodium symporter activity
GO:0016595	glutamate binding
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006811	ion transport
GO:0006835	dicarboxylic acid transport
GO:0007268	synaptic transmission
GO:0015813	L-glutamate transport
GO:0051260	protein homooligomerization
GO:0051938	L-glutamate import
GO:0055085	transmembrane transport
GO:0070779	D-aspartate import

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024935

View Gene Order

ENSBTAG00000019125

Not yet available

Pathways

NETPATH

REACTOME

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_12591

Glutamate Neurotransmitter Release Cycle pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.444915 Hs.662818

RefSeq

NM_004170

HUGO

OMIM

CCDS

CCDS6452

HPRD

00597

IMGT

EMBL

GenPept

RNA Seq Atlas