Version 5.4
Homo sapiens Gene: IL26
Summary
InnateDB Gene IDBG-46009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL26
Gene Name interleukin 26
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000111536
Encoded Proteins
IDBP-46011
interleukin 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:68201351-68225821
Strand Reverse strand
Band q15
Transcripts
ENST00000229134 ENSP00000229134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0007267 cell-cell signaling
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046427 positive regulation of JAK-STAT cascade
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050715 positive regulation of cytokine secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9NPH9
TrEMBL
UniProt Splice Variant
Entrez Gene 55801
UniGene Hs.272350
RefSeq NM_018402
HUGO HGNC:17119
OMIM 605679
CCDS CCDS8981
HPRD
IMGT
EMBL AJ251549 AJ251550 AJ251551 AY509906 BC066270 BC066271
GenPept AAH66270 AAH66271 AAR87776 CAB76942 CAB77049
RNA Seq Atlas 55801

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca