Version 5.4
Homo sapiens Gene: ERBB2
Summary
InnateDB Gene IDBG-46068.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERBB2
Gene Name v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Synonyms CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Species Homo sapiens
Ensembl Gene ENSG00000141736
Encoded Proteins
IDBP-46072
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
IDBP-295365
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
IDBP-377207
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
IDBP-593475
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
IDBP-764868
IDBP-762266
IDBP-759005
IDBP-763320
IDBP-763524
IDBP-758574
IDBP-762846
IDBP-762129
IDBP-760292
IDBP-762949
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39687914-39730426
Strand Forward strand
Band q12
Transcripts
ENST00000269571 ENSP00000269571
ENST00000406381 ENSP00000385185
ENST00000445658 ENSP00000404047
ENST00000541774 ENSP00000446466
ENST00000578502 ENSP00000464420
ENST00000578630
ENST00000582818 ENSP00000464252
ENST00000584888
ENST00000584450 ENSP00000463714
ENST00000582648 ENSP00000462024
ENST00000583391
ENST00000578373 ENSP00000463427
ENST00000583038
ENST00000584099 ENSP00000462270
ENST00000584601 ENSP00000462438
ENST00000582788
ENST00000584014
ENST00000584684
ENST00000578199 ENSP00000462808
ENST00000580074 ENSP00000463002
ENST00000578709 ENSP00000463719
ENST00000584908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 209 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 209 [view]
Protein-Protein 199 [view]
Protein-DNA 7 [view]
Protein-RNA 2 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001042 RNA polymerase I core binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0019903 protein phosphatase binding
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008045 motor neuron axon guidance
GO:0008283 cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030307 positive regulation of cell growth
GO:0030879 mammary gland development
GO:0032321 positive regulation of Rho GTPase activity
GO:0032886 regulation of microtubule-based process
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042060 wound healing
GO:0042552 myelination
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045943 positive regulation of transcription from RNA polymerase I promoter
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048709 oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0070372 regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0043235 receptor complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062312
View Gene Order
ENSBTAG00000021798
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_9
TNFalpha pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_115662
Downregulation of ERBB2:ERBB3 signaling pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115896
GRB7 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_19271
Semaphorin interactions pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa04520
Adherens junction pathway
hsa05213
Endometrial cancer pathway
hsa05219
Bladder cancer pathway
hsa05215
Prostate cancer pathway
hsa04510
Focal adhesion pathway
hsa05212
Pancreatic cancer pathway
hsa04020
Calcium signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
myc_represspathway
Validated targets of C-MYC transcriptional repression
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
erbb_network_pathway
ErbB receptor signaling network
Cross-References
SwissProt
TrEMBL F5H1T4 J3KS21 J3QLV2 Q9NP09
UniProt Splice Variant
Entrez Gene 2064
UniGene Hs.446352
RefSeq XM_005257140 NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448 XM_006721766 XM_006721768
HUGO HGNC:3430
OMIM 164870
CCDS CCDS45667 CCDS32642 CCDS74052
HPRD 01281
IMGT
EMBL AC079199 AC087491 M86910
GenPept AAF30295
RNA Seq Atlas 2064

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca