InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPOCK1

Summary

InnateDB Gene

IDBG-46103.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPOCK1

Gene Name

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Synonyms

SPOCK; TESTICAN; TIC1

Species

Homo sapiens

Ensembl Gene

ENSG00000152377

Encoded Proteins

IDBP-46105

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

IDBP-240563

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

IDBP-480507

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

IDBP-483809

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

IDBP-476645

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein\'s function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:136975298-137598379

Strand

Reverse strand

Band

q31.2

Transcripts

ENST00000282223	ENSP00000282223
ENST00000394945	ENSP00000378401
ENST00000515091
ENST00000509978
ENST00000508642
ENST00000510689	ENSP00000421677
ENST00000510405	ENSP00000421418
ENST00000505690	ENSP00000424517
ENST00000503916
ENST00000509293

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010951	negative regulation of endopeptidase activity
GO:0010977	negative regulation of neuron projection development
GO:0021953	central nervous system neuron differentiation
GO:0022008	neurogenesis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0016528	sarcoplasm
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000056222

View Gene Order

ENSBTAG00000003502

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.582184 Hs.596136 Hs.713459 Hs.714616 Hs.720618

RefSeq

NM_004598

HUGO

OMIM

CCDS

CCDS4191

HPRD

11887

IMGT

EMBL

GenPept

RNA Seq Atlas