Version 5.4
Homo sapiens Gene: APBA2
Summary
InnateDB Gene IDBG-4634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APBA2
Gene Name amyloid beta (A4) precursor protein-binding, family A, member 2
Synonyms D15S1518E; HsT16821; LIN-10; MGC:14091; MINT2; X11-BETA; X11L
Species Homo sapiens
Ensembl Gene ENSG00000034053
Encoded Proteins
IDBP-362906
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-583314
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-589128
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-593850
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-603721
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-600892
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-587519
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-585619
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-594474
amyloid beta (A4) precursor protein-binding, family A, member 2
IDBP-594268
amyloid beta (A4) precursor protein-binding, family A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer\'s disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer\'s disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:28884483-29118315
Strand Forward strand
Band q13.1
Transcripts
ENST00000382938
ENST00000411764 ENSP00000409312
ENST00000561069 ENSP00000453144
ENST00000558402 ENSP00000453293
ENST00000558330 ENSP00000452722
ENST00000559814
ENST00000559709 ENSP00000452699
ENST00000558804 ENSP00000454001
ENST00000560283 ENSP00000453034
ENST00000558206 ENSP00000453981
ENST00000558358 ENSP00000453715
ENST00000558259 ENSP00000454171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007268 synaptic transmission
GO:0007399 nervous system development
GO:0007626 locomotory behavior
GO:0010468 regulation of gene expression
GO:0015031 protein transport
GO:0035264 multicellular organism growth
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030519
View Gene Order
ENSBTAG00000020413
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604355 Hs.618112 Hs.695398 Hs.721380
RefSeq NM_001130414 NM_005503
HUGO
OMIM
CCDS CCDS10022 CCDS45197
HPRD 04090
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca