Homo sapiens Gene: SSRP1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-46402.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | SSRP1 | ||||||||||||||||||||||
Gene Name | structure specific recognition protein 1 | ||||||||||||||||||||||
Synonyms | FACT; FACT80; T160 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000149136 | ||||||||||||||||||||||
Encoded Proteins |
structure specific recognition protein 1
structure specific recognition protein 1
structure specific recognition protein 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 11:57325985-57335877 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q12.1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
Pausing and recovery of HIV elongation pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
HIV Infection pathway
Gene Expression pathway
Disease pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of TAp63 isoforms
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | E9PPZ7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 6749 | ||||||||||||||||||||||
UniGene | Hs.523680 | ||||||||||||||||||||||
RefSeq | NM_003146 XM_005274194 | ||||||||||||||||||||||
HUGO | HGNC:11327 | ||||||||||||||||||||||
OMIM | 604328 | ||||||||||||||||||||||
CCDS | CCDS7952 | ||||||||||||||||||||||
HPRD | 05061 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AP000781 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 6749 | ||||||||||||||||||||||