InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MDM2

Summary

InnateDB Gene

IDBG-46431.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

Synonyms

ACTFS; hdm2; HDMX

Species

Homo sapiens

Ensembl Gene

ENSG00000135679

Encoded Proteins

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Mdm2 p53 binding protein homolog (mouse)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:68808172-68850686

Strand

Forward strand

Band

q15

Transcripts

ENST00000258149	ENSP00000258149
ENST00000350057	ENSP00000266624
ENST00000258148	ENSP00000258148
ENST00000356290	ENSP00000348637
ENST00000299252	ENSP00000299252
ENST00000360430	ENSP00000353611
ENST00000348801	ENSP00000335096
ENST00000311420	ENSP00000310742
ENST00000400501
ENST00000393417	ENSP00000429021
ENST00000393416	ENSP00000377068
ENST00000393415	ENSP00000377067
ENST00000393413	ENSP00000377065
ENST00000393412	ENSP00000377064
ENST00000393410	ENSP00000377062
ENST00000428863	ENSP00000410694
ENST00000462284	ENSP00000417281
ENST00000493419
ENST00000523991	ENSP00000427828
ENST00000517852	ENSP00000430257
ENST00000496959	ENSP00000429692
ENST00000481186	ENSP00000431110
ENST00000478070	ENSP00000430906
ENST00000471946
ENST00000539479	ENSP00000444430
ENST00000543323	ENSP00000439238
ENST00000544561	ENSP00000441841
ENST00000545204	ENSP00000444597
ENST00000546048	ENSP00000445222
ENST00000540352	ENSP00000445030
ENST00000542502	ENSP00000444566
ENST00000537182	ENSP00000443450
ENST00000536089	ENSP00000444028
ENST00000543046
ENST00000540709
ENST00000544125

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 932 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	932 [view]
Protein-Protein	915 [view]
Protein-DNA	10 [view]
Protein-RNA	1 [view]
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089	traversing start control point of mitotic cell cycle
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007268	synaptic transmission
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009636	response to toxic substance
GO:0009743	response to carbohydrate
GO:0010039	response to iron ion
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010955	negative regulation of protein processing
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0018205	peptidyl-lysine modification
GO:0030163	protein catabolic process
GO:0031648	protein destabilization
GO:0032026	response to magnesium ion
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042176	regulation of protein catabolic process
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043278	response to morphine
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response
GO:0045184	establishment of protein localization
GO:0045472	response to ether
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0046677	response to antibiotic
GO:0046827	positive regulation of protein export from nucleus
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048545	response to steroid hormone
GO:0070301	cellular response to hydrogen peroxide
GO:0071157	negative regulation of cell cycle arrest
GO:0071229	cellular response to acid
GO:0071236	cellular response to antibiotic
GO:0071301	cellular response to vitamin B1
GO:0071310	cellular response to organic substance
GO:0071312	cellular response to alkaloid
GO:0071363	cellular response to growth factor stimulus
GO:0071375	cellular response to peptide hormone stimulus
GO:0071391	cellular response to estrogen stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071456	cellular response to hypoxia
GO:0071494	cellular response to UV-C

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016604	nuclear body
GO:0030666	endocytic vesicle membrane
GO:0043234	protein complex
GO:0045202	synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020184

View Gene Order

ENSBTAG00000010422

Not yet available

Pathways

NETPATH

AndrogenReceptor pathway

FSH pathway

REACTOME

Stabilization of p53 pathway

p53-Dependent G1 DNA Damage Response pathway

AKT phosphorylates targets in the cytosol pathway

PIP3 activates AKT signaling pathway

DAP12 signaling pathway

DAP12 interactions pathway

PI3K/AKT activation pathway

GAB1 signalosome pathway

Signaling by EGFR pathway

PI3K events in ERBB4 signaling pathway

Signaling by ERBB4 pathway

PI3K events in ERBB2 signaling pathway

Signaling by ERBB2 pathway

PI-3K cascade pathway

Signaling by FGFR pathway

Signaling by SCF-KIT pathway

Downstream signal transduction pathway

Signaling by PDGF pathway

Constitutive PI3K/AKT Signaling in Cancer pathway

Trafficking of AMPA receptors pathway

Signaling by FGFR in disease pathway

p53-Dependent G1/S DNA damage checkpoint pathway

Cellular responses to stress pathway

Oncogene Induced Senescence pathway

Signalling by NGF pathway

Signaling by EGFR in Cancer pathway

Downstream signaling of activated FGFR pathway

Neuronal System pathway

Role of LAT2/NTAL/LAB on calcium mobilization pathway

Innate Immune System pathway

Fc epsilon receptor (FCERI) signaling pathway

Signal Transduction pathway

Cell Cycle pathway

Adaptive Immune System pathway

Immune System pathway

Cellular Senescence pathway

NGF signalling via TRKA from the plasma membrane pathway

Transmission across Chemical Synapses pathway

PI3K/AKT Signaling in Cancer pathway

G1/S DNA Damage Checkpoints pathway

Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway

Signaling by the B Cell Receptor (BCR) pathway

Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway

Oxidative Stress Induced Senescence pathway

Downstream signaling events of B Cell Receptor (BCR) pathway

Disease pathway

Cell Cycle Checkpoints pathway

KEGG

hsa04110

Cell cycle pathway

hsa05218

Melanoma pathway

hsa05219

Bladder cancer pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05214

Glioma pathway

hsa05215

Prostate cancer pathway

hsa05220

Chronic myeloid leukemia pathway

hsa04115

p53 signaling pathway pathway

hsa04144

Endocytosis pathway

hsa05200

Pathways in cancer pathway

INOH

Tryptophan degradation pathway

PID NCI

Regulation of retinoblastoma protein

aurora_a_pathway

Aurora A signaling

ErbB4 signaling events

p53downstreampathway

Direct p53 effectors

p53regulationpathway

p53 pathway

Glucocorticoid receptor regulatory network

p73 transcription factor network

Sumoylation by RanBP2 regulates transcriptional repression

ATM pathway

ATR signaling pathway

Regulation of Androgen receptor activity

deltanp63pathway

Validated transcriptional targets of deltaNp63 isoforms

Validated transcriptional targets of TAp63 isoforms

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.484551 Hs.743650

RefSeq

NM_001145337 NM_001145339 NM_001145340 NM_001278462 NM_002392 XM_005268872 XM_006719399 XM_006719400

HUGO

OMIM

CCDS

CCDS61189 CCDS8986

HPRD

01272

IMGT

EMBL

GenPept

RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca