Version 5.4
Homo sapiens Gene: P2RX3
Summary
InnateDB Gene IDBG-46464.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX3
Gene Name purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms P2X3
Species Homo sapiens
Ensembl Gene ENSG00000109991
Encoded Proteins
IDBP-46466
purinergic receptor P2X, ligand-gated ion channel, 3
IDBP-593489
purinergic receptor P2X, ligand-gated ion channel, 3
IDBP-810141
purinergic receptor P2X, ligand-gated ion channel, 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57338374-57370600
Strand Forward strand
Band q12.1
Transcripts
ENST00000263314 ENSP00000263314
ENST00000533436
ENST00000534820 ENSP00000434166
ENST00000616487 ENSP00000484614
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
Biological Process
GO:0001666 response to hypoxia
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007274 neuromuscular synaptic transmission
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0009409 response to cold
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0010033 response to organic substance
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0014832 urinary bladder smooth muscle contraction
GO:0019228 neuronal action potential
GO:0030432 peristalsis
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0048167 regulation of synaptic plasticity
GO:0048266 behavioral response to pain
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050909 sensory perception of taste
GO:0051260 protein homooligomerization
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0043235 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027071
View Gene Order
ENSBTAG00000000376
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.693198
RefSeq NM_002559
HUGO
OMIM
CCDS CCDS7953
HPRD 09016
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca