InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POLR2I

Summary

InnateDB Gene

IDBG-46497.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2I

Gene Name

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

Synonyms

hRPB14.5; RPB9

Species

Homo sapiens

Ensembl Gene

ENSG00000105258

Encoded Proteins

IDBP-46499

polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

IDBP-765442

IDBP-762641

IDBP-760269

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:36113710-36115346

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000221859	ENSP00000221859
ENST00000585842	ENSP00000465455
ENST00000586439	ENSP00000467134
ENST00000589069
ENST00000589591
ENST00000586789
ENST00000592962	ENSP00000465755

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity
GO:0008270	zinc ion binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0001193	maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0050434	positive regulation of viral transcription

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005665	DNA-directed RNA polymerase II, core complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019738

View Gene Order

ENSBTAG00000015002

Not yet available

Pathways

NETPATH

REACTOME

REACT_6344

Tat-mediated HIV elongation arrest and recovery pathway

REACT_6143

Pausing and recovery of Tat-mediated HIV elongation pathway

REACT_6354

Viral Messenger RNA Synthesis pathway

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1470

mRNA Capping pathway

REACT_12417

MicroRNA (miRNA) biogenesis pathway

REACT_1655

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway

REACT_22107

RNA Polymerase II Pre-transcription Events pathway

REACT_1845

Formation of RNA Pol II elongation complex pathway

REACT_846

Formation of the Early Elongation Complex pathway

REACT_833

RNA Polymerase II Transcription Elongation pathway

REACT_2089

RNA Polymerase II Promoter Escape pathway

REACT_1851

RNA Polymerase II Transcription Initiation pathway

REACT_834

RNA Polymerase II Transcription Initiation And Promoter Clearance pathway

REACT_975

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_22201

Formation of HIV elongation complex in the absence of HIV Tat pathway

REACT_6332

HIV Transcription Initiation pathway

REACT_6244

Pausing and recovery of HIV elongation pathway

REACT_6253

RNA Polymerase II HIV Promoter Escape pathway

REACT_6319

Formation of the HIV-1 Early Elongation Complex pathway

REACT_6346

Formation of HIV-1 elongation complex containing HIV-1 Tat pathway

REACT_6162

Tat-mediated elongation of the HIV-1 transcript pathway

REACT_6261

Abortive elongation of HIV-1 transcript in the absence of Tat pathway

REACT_6237

RNA Pol II CTD phosphorylation and interaction with CE pathway

REACT_6259

HIV elongation arrest and recovery pathway

REACT_6233

Transcription of the HIV genome pathway

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_1941

Formation of transcription-coupled NER (TC-NER) repair complex pathway

REACT_2222

Dual incision reaction in TC-NER pathway

REACT_1628

Transcription-coupled NER (TC-NER) pathway

REACT_6167

Influenza Infection pathway

REACT_267668

Transcriptional regulation by small RNAs pathway

REACT_6152

Influenza Viral RNA Transcription and Replication pathway

REACT_6274

HIV Transcription Elongation pathway

REACT_1366

RNA Polymerase II Transcription pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6145

Influenza Life Cycle pathway

REACT_1735

mRNA Splicing pathway

REACT_1826

Nucleotide Excision Repair pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

REACT_216

DNA Repair pathway

REACT_12472

Regulatory RNA pathways pathway

KEGG

hsa00240

Pyrimidine metabolism pathway

hsa00230

Purine metabolism pathway

hsa03020

RNA polymerase pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_006233

HUGO

OMIM

CCDS

CCDS12487

HPRD

15944

IMGT

EMBL

GenPept

RNA Seq Atlas