Version 5.4
Homo sapiens Gene: KLF6
Summary
InnateDB Gene IDBG-46758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF6
Gene Name Kruppel-like factor 6
Synonyms BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12; ZF9
Species Homo sapiens
Ensembl Gene ENSG00000067082
Encoded Proteins
IDBP-475187
Kruppel-like factor 6
IDBP-485328
Kruppel-like factor 6
IDBP-597774
Kruppel-like factor 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:3775996-3785281
Strand Reverse strand
Band p15.2
Transcripts
ENST00000173785
ENST00000380946
ENST00000497571 ENSP00000419923
ENST00000461124
ENST00000492125
ENST00000469435 ENSP00000419079
ENST00000542957 ENSP00000445301
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 21 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0019221 cytokine-mediated signaling pathway
GO:0030183 B cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000078
View Gene Order
ENSBTAG00000015188
Not yet available
Cross-References
SwissProt Q99612
TrEMBL Q7Z3W8
UniProt Splice Variant
Entrez Gene 1316
UniGene Hs.4055 Hs.606285 Hs.621623 Hs.709396 Hs.713327
RefSeq NM_001160124 NM_001300 NM_001160125
HUGO HGNC:2235
OMIM 602053
CCDS CCDS7060 CCDS53490
HPRD 03632
IMGT
EMBL AB017493 AF001461 AF284036 AK293259 AK316596 AL450322 AL513303 BC000311 BT006778 BX537374 CH471072 U44975
GenPept AAC23699 AAC39929 AAH00311 AAM73548 AAP35424 BAA33050 BAG38183 BAG56791 CAD97616 CAH71010 CAH71011 CAH74049 CAH74050 EAW86477 EAW86479
RNA Seq Atlas 1316

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca