InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CPSF6

Summary

InnateDB Gene

IDBG-46901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPSF6

Gene Name

cleavage and polyadenylation specific factor 6, 68kDa

Synonyms

CFIM; CFIM68; HPBRII-4; HPBRII-7

Species

Homo sapiens

Ensembl Gene

ENSG00000111605

Encoded Proteins

IDBP-46903

cleavage and polyadenylation specific factor 6, 68kDa

IDBP-379847

cleavage and polyadenylation specific factor 6, 68kDa

IDBP-379852

cleavage and polyadenylation specific factor 6, 68kDa

IDBP-587952

cleavage and polyadenylation specific factor 6, 68kDa

IDBP-594446

cleavage and polyadenylation specific factor 6, 68kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is one subunit of a cleavage factor required for 3\' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3\' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:69239537-69274358

Strand

Forward strand

Band

q15

Transcripts

ENST00000266679	ENSP00000266679
ENST00000435070	ENSP00000391774
ENST00000456847	ENSP00000391437
ENST00000550075	ENSP00000446670
ENST00000550987
ENST00000551516	ENSP00000450206
ENST00000547486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	74 [view]
Protein-Protein	74 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0006397	mRNA processing
GO:0051262	protein tetramerization

Cellular Component

GO:0005634	nucleus
GO:0005849	mRNA cleavage factor complex
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0042382	paraspeckles

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055531

View Gene Order

ENSBTAG00000007323

Not yet available

Pathways

NETPATH

REACTOME

REACT_121141

Signaling by FGFR1 fusion mutants pathway

REACT_121398

Signaling by FGFR mutants pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_120999

Signaling by FGFR1 mutants pathway

REACT_116125

Disease pathway

KEGG

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q16630

TrEMBL

UniProt Splice Variant

Entrez Gene

11052

UniGene

Hs.369606 Hs.611646 Hs.656303 Hs.702826

RefSeq

NM_007007 XM_005268590 NM_001300947 XM_005268589

HUGO

HGNC:13871

OMIM

604979

CCDS

CCDS8988 CCDS73494

HPRD

IMGT

EMBL

AK223568 AK292024 BC000714 BC005000 CH471054 X67336 X67337

GenPept

AAH00714 AAH05000 BAD97288 BAF84713 CAA47751 CAA47752 EAW97215

RNA Seq Atlas

11052