Version 5.4
Homo sapiens Gene: CBFA2T3
Summary
InnateDB Gene IDBG-46976.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBFA2T3
Gene Name core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Synonyms ETO2; MTG16; MTGR2; ZMYND4
Species Homo sapiens
Ensembl Gene ENSG00000129993
Encoded Proteins
IDBP-46978
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
IDBP-46980
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
IDBP-749379
IDBP-747148
IDBP-745572
IDBP-750883
IDBP-751999
IDBP-751836
IDBP-746912
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5\'-region of the runt-related transcription factor 1 gene fused to the 3\'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:88874858-88977204
Strand Reverse strand
Band q24.3
Transcripts
ENST00000268679 ENSP00000268679
ENST00000327483 ENSP00000332122
ENST00000563856
ENST00000570046 ENSP00000456102
ENST00000566868 ENSP00000464125
ENST00000569464 ENSP00000454851
ENST00000564416 ENSP00000454609
ENST00000563920
ENST00000569443 ENSP00000457410
ENST00000562719 ENSP00000456717
ENST00000563640 ENSP00000454872
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0030851 granulocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006362
View Gene Order
ENSBTAG00000010927
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
erbb4_pathway
ErbB4 signaling events
Cross-References
SwissProt O75081
TrEMBL B3KR45 H3BMZ0 H3BNH2 H3BNI7 H3BR72 H3BSI4 H3BU07
UniProt Splice Variant
Entrez Gene 863
UniGene Hs.513811 Hs.717542
RefSeq NM_005187 NM_175931 XM_006721319 XM_006721320
HUGO HGNC:1537
OMIM 603870
CCDS CCDS10972 CCDS10973
HPRD
IMGT
EMBL AB010419 AB010420 AB013286 AC092384 AF052213 AF052214 AF052215 AF052216 AF052217 AF052220 AK090985 BC047019 BC062624 CH471184
GenPept AAC64698 AAC64701 AAC64702 AAH47019 AAH62624 BAA29061 BAA29062 BAA31276 BAA31277 BAG52257 EAW66748 EAW66752
RNA Seq Atlas 863

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca