Version 5.4
Homo sapiens Gene: CTNND1
Summary
InnateDB Gene IDBG-47085.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNND1
Gene Name catenin (cadherin-associated protein), delta 1
Synonyms CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN
Species Homo sapiens
Ensembl Gene ENSG00000198561
Encoded Proteins
IDBP-47095
catenin (cadherin-associated protein), delta 1
IDBP-47097
catenin (cadherin-associated protein), delta 1
IDBP-47099
catenin (cadherin-associated protein), delta 1
IDBP-47101
catenin (cadherin-associated protein), delta 1
IDBP-231375
catenin (cadherin-associated protein), delta 1
IDBP-231377
catenin (cadherin-associated protein), delta 1
IDBP-374784
catenin (cadherin-associated protein), delta 1
IDBP-374787
catenin (cadherin-associated protein), delta 1
IDBP-374789
catenin (cadherin-associated protein), delta 1
IDBP-590183
catenin (cadherin-associated protein), delta 1
IDBP-603700
catenin (cadherin-associated protein), delta 1
IDBP-598474
catenin (cadherin-associated protein), delta 1
IDBP-585397
catenin (cadherin-associated protein), delta 1
IDBP-597111
catenin (cadherin-associated protein), delta 1
IDBP-586517
catenin (cadherin-associated protein), delta 1
IDBP-585557
catenin (cadherin-associated protein), delta 1
IDBP-589211
catenin (cadherin-associated protein), delta 1
IDBP-603695
catenin (cadherin-associated protein), delta 1
IDBP-587754
catenin (cadherin-associated protein), delta 1
IDBP-603692
catenin (cadherin-associated protein), delta 1
IDBP-587344
catenin (cadherin-associated protein), delta 1
IDBP-587636
catenin (cadherin-associated protein), delta 1
IDBP-599926
catenin (cadherin-associated protein), delta 1
IDBP-584039
catenin (cadherin-associated protein), delta 1
IDBP-588226
catenin (cadherin-associated protein), delta 1
IDBP-583972
catenin (cadherin-associated protein), delta 1
IDBP-597735
catenin (cadherin-associated protein), delta 1
IDBP-585601
catenin (cadherin-associated protein), delta 1
IDBP-588614
catenin (cadherin-associated protein), delta 1
IDBP-601659
catenin (cadherin-associated protein), delta 1
IDBP-598642
catenin (cadherin-associated protein), delta 1
IDBP-602080
catenin (cadherin-associated protein), delta 1
IDBP-595738
catenin (cadherin-associated protein), delta 1
IDBP-593536
catenin (cadherin-associated protein), delta 1
IDBP-585260
catenin (cadherin-associated protein), delta 1
IDBP-584148
catenin (cadherin-associated protein), delta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25773174
[Mus musculus] Ctnnd1 expressed in alveolar type II epithelial cells plays a critical role in regulating the innate immunity of the entire lung.
Entrez Gene
Summary This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:57753243-57819546
Strand Forward strand
Band q12.1
Transcripts
ENST00000361332 ENSP00000354823
ENST00000361796 ENSP00000354907
ENST00000361391 ENSP00000354785
ENST00000358694 ENSP00000351527
ENST00000399050 ENSP00000382004
ENST00000399039 ENSP00000381996
ENST00000428599 ENSP00000413586
ENST00000415361 ENSP00000403518
ENST00000426142 ENSP00000409930
ENST00000524630 ENSP00000436543
ENST00000529919 ENSP00000434808
ENST00000533189 ENSP00000435242
ENST00000529526 ENSP00000436323
ENST00000532463 ENSP00000432075
ENST00000529986 ENSP00000437156
ENST00000532787 ENSP00000434949
ENST00000533667 ENSP00000437051
ENST00000532649 ENSP00000435379
ENST00000528621 ENSP00000432243
ENST00000530748 ENSP00000436744
ENST00000527467 ENSP00000434900
ENST00000528232 ENSP00000435266
ENST00000531014 ENSP00000432623
ENST00000526772 ENSP00000433158
ENST00000529873 ENSP00000435494
ENST00000525902 ENSP00000434672
ENST00000532844 ENSP00000433276
ENST00000526357 ENSP00000433334
ENST00000530094 ENSP00000437327
ENST00000532245 ENSP00000434017
ENST00000534579 ENSP00000435789
ENST00000526938 ENSP00000432041
ENST00000524579 ENSP00000432299
ENST00000530068 ENSP00000431600
ENST00000534647 ENSP00000434202
ENST00000527599
ENST00000530720
ENST00000531007 ENSP00000431208
ENST00000525821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007420 brain development
GO:0016055 Wnt signaling pathway
GO:0016337 single organismal cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005915 zonula adherens
GO:0030027 lamellipodium
GO:0030426 growth cone
GO:0030496 midbody
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034101
View Gene Order
ENSBTAG00000002411
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_19195
Adherens junctions interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_12529
Signaling by VEGF pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
fgf_pathway
FGF signaling pathway
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
arf6_traffickingpathway
Arf6 trafficking events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.166011
RefSeq NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465 NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001206883 NM_001206884 NM_001206885 NM_001206886 NM_001206887 NM_001206888 NM_001206889 NM_001206890 NM_001206891 NM_001331
HUGO
OMIM
CCDS CCDS44604 CCDS44605 CCDS44606 CCDS44607 CCDS44608 CCDS44609 CCDS53632 CCDS53633 CCDS53634 CCDS55763 CCDS55764 CCDS55765 CCDS55766 CCDS55767 CCDS73290
HPRD 03026
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca