Version 5.4
Homo sapiens Gene: SORBS2
Summary
InnateDB Gene IDBG-47102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SORBS2
Gene Name sorbin and SH3 domain containing 2
Synonyms ARGBP2; PRO0618
Species Homo sapiens
Ensembl Gene ENSG00000154556
Encoded Proteins
IDBP-47104
sorbin and SH3 domain containing 2
IDBP-47106
sorbin and SH3 domain containing 2
IDBP-47108
sorbin and SH3 domain containing 2
IDBP-47110
sorbin and SH3 domain containing 2
IDBP-243435
sorbin and SH3 domain containing 2
IDBP-243437
sorbin and SH3 domain containing 2
IDBP-380661
sorbin and SH3 domain containing 2
IDBP-380664
sorbin and SH3 domain containing 2
IDBP-380668
sorbin and SH3 domain containing 2
IDBP-380673
sorbin and SH3 domain containing 2
IDBP-380697
sorbin and SH3 domain containing 2
IDBP-380701
sorbin and SH3 domain containing 2
IDBP-380705
sorbin and SH3 domain containing 2
IDBP-380708
sorbin and SH3 domain containing 2
IDBP-380713
sorbin and SH3 domain containing 2
IDBP-380714
sorbin and SH3 domain containing 2
IDBP-380716
sorbin and SH3 domain containing 2
IDBP-380717
sorbin and SH3 domain containing 2
IDBP-380719
sorbin and SH3 domain containing 2
IDBP-380723
sorbin and SH3 domain containing 2
IDBP-380727
sorbin and SH3 domain containing 2
IDBP-380729
sorbin and SH3 domain containing 2
IDBP-380730
sorbin and SH3 domain containing 2
IDBP-380732
sorbin and SH3 domain containing 2
IDBP-380733
sorbin and SH3 domain containing 2
IDBP-380736
sorbin and SH3 domain containing 2
IDBP-380738
sorbin and SH3 domain containing 2
IDBP-380741
sorbin and SH3 domain containing 2
IDBP-380743
sorbin and SH3 domain containing 2
IDBP-380745
sorbin and SH3 domain containing 2
IDBP-380747
sorbin and SH3 domain containing 2
IDBP-380748
sorbin and SH3 domain containing 2
IDBP-380750
sorbin and SH3 domain containing 2
IDBP-380752
sorbin and SH3 domain containing 2
IDBP-380755
sorbin and SH3 domain containing 2
IDBP-380757
sorbin and SH3 domain containing 2
IDBP-380760
sorbin and SH3 domain containing 2
IDBP-380761
sorbin and SH3 domain containing 2
IDBP-380763
sorbin and SH3 domain containing 2
IDBP-380765
sorbin and SH3 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:185585444-185956652
Strand Reverse strand
Band q35.1
Transcripts
ENST00000355634 ENSP00000347852
ENST00000284776 ENSP00000284776
ENST00000319454 ENSP00000321983
ENST00000319471 ENSP00000322182
ENST00000393528 ENSP00000377162
ENST00000393523 ENSP00000377158
ENST00000449407 ENSP00000397262
ENST00000448662 ENSP00000409158
ENST00000437304 ENSP00000396008
ENST00000418609 ENSP00000397482
ENST00000451974 ENSP00000401818
ENST00000438278 ENSP00000389995
ENST00000445625 ENSP00000391940
ENST00000445343 ENSP00000399048
ENST00000439914 ENSP00000408909
ENST00000444771 ENSP00000410483
ENST00000450341 ENSP00000415680
ENST00000430503 ENSP00000405349
ENST00000445115 ENSP00000397664
ENST00000457247 ENSP00000398335
ENST00000456596 ENSP00000410967
ENST00000425679 ENSP00000415637
ENST00000439049 ENSP00000416464
ENST00000451958 ENSP00000405092
ENST00000444781 ENSP00000396183
ENST00000414724 ENSP00000403417
ENST00000419063 ENSP00000408504
ENST00000420158 ENSP00000410233
ENST00000421639 ENSP00000405646
ENST00000457934 ENSP00000405314
ENST00000431902 ENSP00000405432
ENST00000415274 ENSP00000415392
ENST00000435480 ENSP00000415166
ENST00000432655 ENSP00000407006
ENST00000451701 ENSP00000404430
ENST00000428330 ENSP00000402328
ENST00000421420 ENSP00000393258
ENST00000452351 ENSP00000412447
ENST00000429056 ENSP00000390162
ENST00000456060 ENSP00000389829
ENST00000478461
ENST00000498125
ENST00000480146
ENST00000487184
ENST00000487836
ENST00000495932
ENST00000490562
ENST00000492104
ENST00000490779
ENST00000492810
ENST00000476311
ENST00000466289
ENST00000485380
ENST00000470685
ENST00000494140
ENST00000493709
ENST00000464975
ENST00000464819
ENST00000478249
ENST00000463104
ENST00000476878
ENST00000462661
ENST00000469627
ENST00000488562
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 45 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity
GO:0008307 structural constituent of muscle
GO:0019904 protein domain specific binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0008150 biological_process
GO:0016477 cell migration
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031626
View Gene Order
ENSBTAG00000016486
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.620021 Hs.655143 Hs.742471
RefSeq NM_001145670 NM_001145671 NM_001145672 NM_001145673 NM_001145674 NM_001145675 NM_001270771 NM_003603 NM_021069 XM_005263311 XM_006714390
HUGO
OMIM
CCDS CCDS3845 CCDS43289 CCDS47173 CCDS47174 CCDS47175 CCDS47176 CCDS54825 CCDS59482
HPRD 12473
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca