Version 5.4
Homo sapiens Gene: TFG
Summary
InnateDB Gene IDBG-47460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFG
Gene Name TRK-fused gene
Synonyms HMSNP; SPG57; TF6; TRKT3
Species Homo sapiens
Ensembl Gene ENSG00000114354
Encoded Proteins
IDBP-47462
TRK-fused gene
IDBP-381786
TRK-fused gene
IDBP-475369
TRK-fused gene
IDBP-482052
TRK-fused gene
IDBP-476811
TRK-fused gene
IDBP-477443
TRK-fused gene
IDBP-476049
TRK-fused gene
IDBP-810209
TRK-fused gene
IDBP-810220
TRK-fused gene
IDBP-810222
TRK-fused gene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:100709331-100748966
Strand Forward strand
Band q12.2
Transcripts
ENST00000240851 ENSP00000240851
ENST00000418917 ENSP00000397182
ENST00000490574 ENSP00000419960
ENST00000479672 ENSP00000419559
ENST00000476228 ENSP00000417952
ENST00000463568 ENSP00000419504
ENST00000487505 ENSP00000420797
ENST00000481203
ENST00000612059 ENSP00000477562
ENST00000615993 ENSP00000479269
ENST00000620299 ENSP00000479981
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007165 signal transduction
GO:0008219 cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022757
View Gene Order
ENSBTAG00000016363
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05216
Thyroid cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JJP5 C9JTY3 C9JUE0 K0J5S8 K0J6K2
UniProt Splice Variant
Entrez Gene 10342
UniGene
RefSeq NM_001007565 NM_001195478 NM_001195479 NM_006070 XM_005247066 XM_006713472 XM_006713473
HUGO HGNC:11758
OMIM 602498
CCDS CCDS2939 CCDS56266
HPRD
IMGT
EMBL AB731569 AB731570 AC069223
GenPept BAM48926 BAM48927
RNA Seq Atlas 10342

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca