Version 5.4
Homo sapiens Gene: TOP2A
Summary
InnateDB Gene IDBG-47552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP2A
Gene Name topoisomerase (DNA) II alpha 170kDa
Synonyms TOP2; TP2A
Species Homo sapiens
Ensembl Gene ENSG00000131747
Encoded Proteins
IDBP-377778
topoisomerase (DNA) II alpha 170kDa
IDBP-763766
IDBP-760056
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40388516-40417950
Strand Reverse strand
Band q21.2
Transcripts
ENST00000423485 ENSP00000411532
ENST00000577541 ENSP00000464055
ENST00000577706
ENST00000578412
ENST00000581055 ENSP00000462908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 81 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008094 DNA-dependent ATPase activity
GO:0008144 drug binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000278 mitotic cell cycle
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006265 DNA topological change
GO:0006266 DNA ligation
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006312 mitotic recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0030261 chromosome condensation
GO:0030263 apoptotic chromosome condensation
GO:0040016 embryonic cleavage
GO:0043065 positive regulation of apoptotic process
GO:0044774 mitotic DNA integrity checkpoint
GO:0045070 positive regulation of viral genome replication
GO:0045870 positive regulation of retroviral genome replication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000228 nuclear chromosome
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005814 centriole
GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035 viral integration complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020914
View Gene Order
ENSBTAG00000019262
Not yet available
Pathways
NETPATH
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt P11388
TrEMBL J3KTB7 J3QR57
UniProt Splice Variant
Entrez Gene 7153
UniGene Hs.156346 Hs.654618
RefSeq NM_001067 XM_005257632
HUGO HGNC:11989
OMIM 126430
CCDS CCDS45672
HPRD
IMGT
EMBL AC080112 AF064590 AF069522 AF071738 AF071739 AF071740 AF071741 AF071742 AF071743 AF071744 AF071745 AF071746 AF071747 AF285157 AF285158 AF285159 AJ011741 AJ011742 AJ011743 AJ011744 AJ011745 AJ011746 AJ011747 AJ011748 AJ011749 AJ011750 AJ011751 AJ011752 AJ011753 AJ011754 AJ011755 AJ011756 AJ011757 AJ011758 BC140791 CH471152 J04088
GenPept AAA61209 AAC16736 AAC23518 AAC77388 AAG13403 AAG13404 AAG13405 AAI40792 CAA09762 EAW60663
RNA Seq Atlas 7153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca