InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPL13

Summary

InnateDB Gene

IDBG-47646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPL13

Gene Name

ribosomal protein L13

Synonyms

BBC1; D16S444E; D16S44E; L13

Species

Homo sapiens

Ensembl Gene

ENSG00000167526

Encoded Proteins

IDBP-47648

ribosomal protein L13

IDBP-244294

ribosomal protein L13

IDBP-590695

ribosomal protein L13

IDBP-754279

IDBP-752652

IDBP-750006

IDBP-751241

IDBP-744919

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:89560657-89566828

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000311528	ENSP00000307889
ENST00000399461
ENST00000393099	ENSP00000376811
ENST00000452368	ENSP00000438959
ENST00000491523
ENST00000484610
ENST00000487034
ENST00000467736	ENSP00000464612
ENST00000472354	ENSP00000462380
ENST00000567815	ENSP00000455009
ENST00000563270	ENSP00000457686
ENST00000565571
ENST00000563749
ENST00000570149
ENST00000562879	ENSP00000457174

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 131 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	131 [view]
Protein-Protein	129 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000740

View Gene Order

ENSBTAG00000012044

Not yet available

Pathways

NETPATH

REACTOME

REACT_79

L13a-mediated translational silencing of Ceruloplasmin expression pathway

REACT_75768

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway

REACT_75822

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway

REACT_2085

GTP hydrolysis and joining of the 60S ribosomal subunit pathway

REACT_1797

Formation of a pool of free 40S subunits pathway

REACT_1986

Eukaryotic Translation Termination pathway

REACT_1404

Peptide chain elongation pathway

REACT_1477

Eukaryotic Translation Elongation pathway

REACT_115902

SRP-dependent cotranslational protein targeting to membrane pathway

REACT_9491

Viral mRNA Translation pathway

REACT_2159

Eukaryotic Translation Initiation pathway

REACT_6167

Influenza Infection pathway

REACT_75886

Nonsense-Mediated Decay (NMD) pathway

REACT_6152

Influenza Viral RNA Transcription and Replication pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_2099

Cap-dependent Translation Initiation pathway

REACT_6145

Influenza Life Cycle pathway

REACT_71

Gene Expression pathway

REACT_116125

Disease pathway

KEGG

hsa03010

Ribosome pathway

INOH

PID NCI

Cross-References

SwissProt

P26373

TrEMBL

A8K4C8 H3BUK8 J3QSB4 O60250

UniProt Splice Variant

Entrez Gene

6137

UniGene

Hs.410817

RefSeq

NM_000977 NM_001243130 NM_001243131 NM_033251

HUGO

HGNC:10303

OMIM

113703

CCDS

CCDS10979 CCDS58492

HPRD

06428

IMGT

EMBL

AB007172 AB062392 AC092123 AK127579 AK290893 AK297198 BC004954 BC007345 BC007563 BC007805 BC010994 BC013078 BC014167 BC020804 BC027463 BC063378 BC093063 BC106058 CH471184 X64707

GenPept

AAH04954 AAH07345 AAH07563 AAH07805 AAH10994 AAH13078 AAH14167 AAH20804 AAH27463 AAH63378 AAH93063 AAI06059 BAA25832 BAB93479 BAF83582 BAG54527 BAG59685 CAA45963 EAW66724 EAW66725

RNA Seq Atlas

606500 6137