Version 5.4
Homo sapiens Gene: CCR7
Summary
InnateDB Gene IDBG-47801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCR7
Gene Name chemokine (C-C motif) receptor 7
Synonyms BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1
Species Homo sapiens
Ensembl Gene ENSG00000126353
Encoded Proteins
IDBP-47803
chemokine (C-C motif) receptor 7
IDBP-764203
IDBP-759616
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20176793
CCR7 is a chemokine receptor expressed on the surfaces of T cells, B cells, and mature dendritic cells that controls cell migration in response to the cognate ligands CCL19 and CCL21. CCR7 deficiency results in a heightened pro-inflammatory environment in response to acute pulmonary P. aeruginosa infection and contributes to more efficient clearance.
Entrez Gene
Summary The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40553769-40565472
Strand Reverse strand
Band q21.2
Transcripts
ENST00000246657 ENSP00000246657
ENST00000578085 ENSP00000463075
ENST00000579344 ENSP00000462631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0016493 C-C chemokine receptor activity
GO:0035757 chemokine (C-C motif) ligand 19 binding
GO:0035758 chemokine (C-C motif) ligand 21 binding
GO:0038117 C-C motif chemokine 19 receptor activity
GO:0038121 C-C motif chemokine 21 receptor activity
Biological Process
GO:0001768 establishment of T cell polarity
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002407 dendritic cell chemotaxis
GO:0002408 myeloid dendritic cell chemotaxis
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002885 positive regulation of hypersensitivity
GO:0002922 positive regulation of humoral immune response
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0030838 positive regulation of actin filament polymerization
GO:0031274 positive regulation of pseudopodium assembly
GO:0031529 ruffle organization
GO:0032496 response to lipopolysaccharide
GO:0032649 regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032862 activation of Rho GTPase activity
GO:0034695 response to prostaglandin E
GO:0038115 chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045060 negative thymic T cell selection
GO:0045087 innate immune response (InnateDB)
GO:0045785 positive regulation of cell adhesion
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0050706 regulation of interleukin-1 beta secretion
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051491 positive regulation of filopodium assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0071731 response to nitric oxide
GO:0072610 interleukin-12 secretion
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0097022 lymphocyte migration into lymph node
GO:0097029 mature dendritic cell differentiation
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2000510 positive regulation of dendritic cell chemotaxis
GO:2000522 positive regulation of immunological synapse formation
GO:2000525 positive regulation of T cell costimulation
GO:2000526 positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
GO:2000547 regulation of dendritic cell dendrite assembly
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037944
View Gene Order
ENSBTAG00000015133
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KTN5
UniProt Splice Variant
Entrez Gene 1236
UniGene Hs.370036
RefSeq NM_001838
HUGO HGNC:1608
OMIM 600242
CCDS CCDS11369
HPRD 02588
IMGT
EMBL AC004585
GenPept
RNA Seq Atlas 1236

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca