InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC8A1

Summary

InnateDB Gene

IDBG-47824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC8A1

Gene Name

solute carrier family 8 (sodium/calcium exchanger), member 1

Synonyms

NCX1

Species

Homo sapiens

Ensembl Gene

ENSG00000183023

Encoded Proteins

IDBP-47828

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293878

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293880

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293874

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293868

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293866

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293863

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293861

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-293865

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-373583

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-373587

solute carrier family 8 (sodium/calcium exchanger), member 1

IDBP-373590

solute carrier family 8 (sodium/calcium exchanger), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:40097270-40611053

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000332839	ENSP00000332931
ENST00000406391	ENSP00000385811
ENST00000408028	ENSP00000384908
ENST00000405901	ENSP00000385678
ENST00000406785	ENSP00000383886
ENST00000403092	ENSP00000384763
ENST00000402441	ENSP00000385188
ENST00000405269	ENSP00000385535
ENST00000407929	ENSP00000386116
ENST00000448531	ENSP00000398575
ENST00000455476	ENSP00000389330
ENST00000417271	ENSP00000412560

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008092	cytoskeletal protein binding
GO:0030506	ankyrin binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding

Biological Process

GO:0001892	embryonic placenta development
GO:0002026	regulation of the force of heart contraction
GO:0002027	regulation of heart rate
GO:0003007	heart morphogenesis
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006816	calcium ion transport
GO:0006936	muscle contraction
GO:0007154	cell communication
GO:0007596	blood coagulation
GO:0009791	post-embryonic development
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014829	vascular smooth muscle contraction
GO:0034614	cellular response to reactive oxygen species
GO:0035050	embryonic heart tube development
GO:0035725	sodium ion transmembrane transport
GO:0044557	relaxation of smooth muscle
GO:0048747	muscle fiber development
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055013	cardiac muscle cell development
GO:0055074	calcium ion homeostasis
GO:0055085	transmembrane transport
GO:0055119	relaxation of cardiac muscle
GO:0060048	cardiac muscle contraction
GO:0060401	cytosolic calcium ion transport
GO:0060402	calcium ion transport into cytosol
GO:0070509	calcium ion import
GO:0071313	cellular response to caffeine
GO:0071436	sodium ion export
GO:0086064	cell communication by electrical coupling involved in cardiac conduction
GO:0097369	sodium ion import
GO:1901660	calcium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030018	Z disc
GO:0030315	T-tubule
GO:0042383	sarcolemma

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000054640

View Gene Order

ENSBTAG00000013861

Not yet available

Pathways

NETPATH

REACTOME

REACT_23765

Reduction of cytosolic Ca++ levels pathway

REACT_23876

Platelet homeostasis pathway

REACT_19320

Sodium/Calcium exchangers pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_23905

Platelet calcium homeostasis pathway

REACT_19118

SLC-mediated transmembrane transport pathway

REACT_604

Hemostasis pathway

KEGG

hsa04020

Calcium signaling pathway pathway

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.468274 Hs.610508 Hs.624386

RefSeq

NM_001112800 NM_001112801 NM_001112802 NM_001252624 NM_021097 XM_005264513 XM_005264514

HUGO

OMIM

CCDS

CCDS1806 CCDS46264 CCDS46265 CCDS59430

HPRD

01659

IMGT

EMBL

GenPept

RNA Seq Atlas