Version 5.4
Homo sapiens Gene: SMARCE1
Summary
InnateDB Gene IDBG-47847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCE1
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Synonyms BAF57
Species Homo sapiens
Ensembl Gene ENSG00000073584
Encoded Proteins
IDBP-47849
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
IDBP-761074
IDBP-47853
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
IDBP-377847
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
IDBP-597048
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
IDBP-377850
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
IDBP-759302
IDBP-763972
IDBP-759773
IDBP-757884
IDBP-760415
IDBP-762746
IDBP-763541
IDBP-763233
IDBP-758698
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17669635
SMARCE1 is a transcriptional modulator that is known to repress viral replication.
PMID 16135788
SMARCE1 is associated with up-regulation of proapoptotic genes, including the tumour suppressor familial cylindromatosis (CYLD).
Entrez Gene
Summary The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40624962-40648508
Strand Reverse strand
Band q21.2
Transcripts
ENST00000348513 ENSP00000323967
ENST00000264640 ENSP00000466608
ENST00000377808 ENSP00000367039
ENST00000400122 ENSP00000411607
ENST00000431889 ENSP00000445370
ENST00000447024 ENSP00000392958
ENST00000469334
ENST00000478349 ENSP00000463216
ENST00000493660
ENST00000481231 ENSP00000462381
ENST00000474246 ENSP00000463405
ENST00000578112 ENSP00000464501
ENST00000580419 ENSP00000462475
ENST00000578044 ENSP00000464511
ENST00000582955 ENSP00000463282
ENST00000583294
ENST00000578995
ENST00000577721 ENSP00000462857
ENST00000580654 ENSP00000464061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 112 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008080 N-acetyltransferase activity
GO:0016922 ligand-dependent nuclear receptor binding
GO:0031492 nucleosomal DNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0043044 ATP-dependent chromatin remodeling
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000228 nuclear chromosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0016514 SWI/SNF complex
GO:0017053 transcriptional repressor complex
GO:0043234 protein complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037935
View Gene Order
ENSBTAG00000015308
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_9
TNFalpha pathway
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643780
RefSeq NM_003079
HUGO
OMIM
CCDS CCDS11370
HPRD 04382
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca