InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RARRES2

Summary

InnateDB Gene

IDBG-47881.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RARRES2

Gene Name

retinoic acid receptor responder (tazarotene induced) 2

Synonyms

HP10433; TIG2

Species

Homo sapiens

Ensembl Gene

ENSG00000106538

Encoded Proteins

IDBP-47883

retinoic acid receptor responder (tazarotene induced) 2

IDBP-485192

retinoic acid receptor responder (tazarotene induced) 2

IDBP-483186

retinoic acid receptor responder (tazarotene induced) 2

IDBP-474592

retinoic acid receptor responder (tazarotene induced) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21715684

RARRES2 (Chemerin) requires C-terminal proteolytic processing by cysteine cathepsins to selectively attract a specific subset of immunoregulatory APCs, such as immature plasmacytoid dendritic cells. In addition, truncated RARRES2 also displays antibacterial activity against Enterobacteriaceae.

InnateDB Annotation from Orthologs

Summary

PMID 21715684

[Mus musculus] Rarres2 (Chemerin) requires C-terminal proteolytic processing by cysteine cathepsins to selectively attract a specific subset of immunoregulatory APCs, such as immature plasmacytoid dendritic cells. In addition, truncated Rarres2 also displays antibacterial activity against Enterobacteriaceae. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine, and is truncated on both termini from the proprotein. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:150338317-150341674

Strand

Reverse strand

Band

q36.1

Transcripts

ENST00000223271	ENSP00000223271
ENST00000478771
ENST00000467793	ENSP00000417669
ENST00000466675	ENSP00000418009
ENST00000482669	ENSP00000418483

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0001701	in utero embryonic development
GO:0001934	positive regulation of protein phosphorylation
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0010759	positive regulation of macrophage chemotaxis
GO:0045087	innate immune response (InnateDB)
GO:0045600	positive regulation of fat cell differentiation
GO:0048566	embryonic digestive tract development
GO:0050873	brown fat cell differentiation
GO:0050921	positive regulation of chemotaxis
GO:0050994	regulation of lipid catabolic process
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005576	extracellular region
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000009281

View Gene Order

ENSBTAG00000004215

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.647064

RefSeq

NM_002889

HUGO

OMIM

CCDS

CCDS5902

HPRD

03577

IMGT

EMBL

GenPept

RNA Seq Atlas