Homo sapiens Gene: UBE2D2 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-47921.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | UBE2D2 | ||||||||||||||||||||||||||||
Gene Name | ubiquitin-conjugating enzyme E2D 2 | ||||||||||||||||||||||||||||
Synonyms | E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000131508 | ||||||||||||||||||||||||||||
Encoded Proteins |
ubiquitin-conjugating enzyme E2D 2
ubiquitin-conjugating enzyme E2D 2
ubiquitin-conjugating enzyme E2D 2
ubiquitin-conjugating enzyme E2D 2
ubiquitin-conjugating enzyme E2D 2
ubiquitin-conjugating enzyme E2D 2
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
Summary |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Jul 2008] Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 5:139526431-139628433 | ||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||
Band | q31.2 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH |
TGF_beta_Receptor pathway
TNFalpha pathway
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REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Negative regulators of RIG-I/MDA5 signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
Cellular responses to stress pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Adaptive Immune System pathway
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
Immune System pathway
Cellular response to hypoxia pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
TRIF-mediated TLR3/TLR4 signaling pathway
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KEGG |
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
Shigellosis pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | P62837 | ||||||||||||||||||||||||||||
TrEMBL | D6RAW0 D6RFM0 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 7322 | ||||||||||||||||||||||||||||
UniGene | Hs.108332 | ||||||||||||||||||||||||||||
RefSeq | NM_003339 NM_181838 | ||||||||||||||||||||||||||||
HUGO | HGNC:12475 | ||||||||||||||||||||||||||||
OMIM | 602962 | ||||||||||||||||||||||||||||
CCDS | CCDS43369 CCDS47275 | ||||||||||||||||||||||||||||
HPRD | 04268 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AC010378 AC018797 AF317220 AK001311 AK001428 AY651263 BC033349 CH471062 L40146 U39317 | ||||||||||||||||||||||||||||
GenPept | AAA91460 AAC41750 AAH33349 AAK93958 AAX35690 BAG50891 BAG50911 EAW62095 EAW62096 EAW62097 | ||||||||||||||||||||||||||||
RNA Seq Atlas | 7322 | ||||||||||||||||||||||||||||