InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AKR1C3

Summary

InnateDB Gene

IDBG-47964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1C3

Gene Name

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

Synonyms

DD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; PGFS

Species

Homo sapiens

Ensembl Gene

ENSG00000196139

Encoded Proteins

IDBP-47966

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

IDBP-362958

aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

IDBP-813412

aldo-keto reductase family 1, member C3

IDBP-813418

aldo-keto reductase family 1, member C3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:5035354-5107686

Strand

Forward strand

Band

p15.1

Transcripts

ENST00000380554	ENSP00000369927
ENST00000439082	ENSP00000401327
ENST00000470862
ENST00000480822
ENST00000480697
ENST00000605781
ENST00000602997	ENSP00000474188
ENST00000605149	ENSP00000474882
ENST00000605322
ENST00000603312
ENST00000603484

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004033	aldo-keto reductase (NADP) activity
GO:0004745	retinol dehydrogenase activity
GO:0004958	prostaglandin F receptor activity
GO:0016491	oxidoreductase activity
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636	phenanthrene 9,10-monooxygenase activity
GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity
GO:0036131	prostaglandin D2 11-ketoreductase activity
GO:0045550	geranylgeranyl reductase activity
GO:0045703	ketoreductase activity
GO:0047017	prostaglandin-F synthase activity
GO:0047020	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023	androsterone dehydrogenase activity
GO:0047035	testosterone dehydrogenase (NAD+) activity
GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086	ketosteroid monooxygenase activity
GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718	indanol dehydrogenase activity
GO:0047787	delta4-3-oxosteroid 5beta-reductase activity

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0001523	retinoid metabolic process
GO:0006693	prostaglandin metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0007603	phototransduction, visible light
GO:0008202	steroid metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0010942	positive regulation of cell death
GO:0016488	farnesol catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019371	cyclooxygenase pathway
GO:0030216	keratinocyte differentiation
GO:0034614	cellular response to reactive oxygen species
GO:0034694	response to prostaglandin stimulus
GO:0042448	progesterone metabolic process
GO:0042574	retinal metabolic process
GO:0044259	multicellular organismal macromolecule metabolic process
GO:0044281	small molecule metabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0048385	regulation of retinoic acid receptor signaling pathway
GO:0051897	positive regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:0061370	testosterone biosynthetic process
GO:0070293	renal absorption
GO:0071276	cellular response to cadmium ion
GO:0071277	cellular response to calcium ion
GO:0071379	cellular response to prostaglandin stimulus
GO:0071384	cellular response to corticosteroid stimulus
GO:0071395	cellular response to jasmonic acid stimulus
GO:1900053	negative regulation of retinoic acid biosynthetic process
GO:2000224	regulation of testosterone biosynthetic process
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process