Version 5.4
Homo sapiens Gene: KRT10
Summary
InnateDB Gene IDBG-48183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT10
Gene Name keratin 10
Synonyms BCIE; BIE; CK10; EHK; K10; KPP
Species Homo sapiens
Ensembl Gene ENSG00000186395
Encoded Proteins
IDBP-48185
keratin 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40818117-40822595
Strand Reverse strand
Band q21.2
Transcripts
ENST00000269576 ENSP00000269576
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 57 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0030280 structural constituent of epidermis
Biological Process
GO:0030216 keratinocyte differentiation
GO:0030855 epithelial cell differentiation
GO:0071277 cellular response to calcium ion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019761
View Gene Order
ENSBTAG00000020824
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05150
Staphylococcus aureus infection pathway
INOH
PID NCI
Cross-References
SwissProt P13645
TrEMBL
UniProt Splice Variant
Entrez Gene 3858
UniGene Hs.99936
RefSeq NM_000421 XM_005257343
HUGO HGNC:6413
OMIM 148080
CCDS CCDS11377
HPRD
IMGT
EMBL AC090283 BC034697 J04029 L20218 L20219 M19156 M77663 X14487
GenPept AAA59199 AAA59468 AAA60544 AAB59438 AAB59439 AAH34697 CAA32649
RNA Seq Atlas 3858

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca